Investigation of causes of FUO (fever of unknown origin) in children

Park, Hyun-Seok; Im, Sun Ju; Park, Su Eun

doi:10.3345/kjp.2006.49.12.1282

Cited by 4 publications

(12 citation statements)

References 16 publications

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“…Among the eight studies in developed countries, infectious disease was the most common etiology in 6 studies and no diagnosis was most common etiology in 2 studies that were performed in the United States67). Similarly, in a previous Korean study from 1999 to 20043), infectious disease was also the most common etiology (41.7%), and 27.5% of patients were undiagnosed. Of note, our study showed that undiagnosed patients made up the greatest proportion of FUO cases.…”

Section: Discussionmentioning

confidence: 89%

“…Most viral febrile episodes usually resolve within 1 week and parents typically take their children to the hospital when the fever lasts more than 7 days. Therefore, in recent studies, definitions of pediatric FUO have tended to include patients with unexplained fever that persists longer than 1 or 2 weeks123).…”

Section: Introductionmentioning

confidence: 99%

“…However, the causes of FUO have changed over the years and have been influenced by diagnostic techniques. Due to the development of improved diagnostic techniques, the proportion of FUO caused by infectious diseases has tended to decrease and the proportion of CTD, malignancies, and other diseases has tended to increase34).…”

Section: Introductionmentioning

confidence: 99%

“…There has been no published research on the etiologies and clinical characteristics of pediatric FUO in Korea since 20063). The aims of this study are to investigate the etiology, clinical characteristics, and prognosis of pediatric FUO and to analyze the factors that can predict certain disease categories.…”

Section: Introductionmentioning

confidence: 99%

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Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Kim

Kang

et al. 2017

Korean J Pediatr

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PurposeFever is one of the most common symptoms in children. In previous studies, infectious disease was the most common cause of pediatric fever of unknown origin (FUO). The aim of this study is to investigate the etiology, clinical characteristics and prognosis of pediatric FUO in 21 century with more diagnostics available and to analyze the factors for certain disease categories.MethodsAmong the children under 18 years old who were hospitalized at Samsung Medical Center from January 2000 to December 2014, the patients who met the criteria including fever of ≥38.0℃ for longer than ≥14 days and failure to reach a diagnosis after one week of investigations were included.ResultsTotal 100 patients were identified. Confirmed diagnosis was achieved in 57 patients (57%). Among them, infectious diseases (n=19, 19%) were most common, followed by connective tissue diseases (n=15, 15%), necrotizing lymphadenitis (n=8, 8%), and malignancies (n=7, 7%). Children with fever duration over 28 days had a trend for higher frequency of connective tissue diseases (28.3%) except undiagnosed etiology. The symptoms such as arthritis, lymph node enlargement and only fever without other symptoms were significantly related with connective tissue diseases, necrotizing lymphadenitis and undiagnosed respectively (P<0.001). Ninety-two patients have become afebrile at discharge and 1 patient died (1%).ConclusionAlmost half of our patients were left without diagnosis. Although it has been known that infectious disease was most common cause of pediatric FUO in the past, undiagnosed portion of FUO have now increased due to development of diagnostic techniques for infectious diseases.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Kim

Kang

et al. 2017

Korean J Pediatr

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“…2,11 Sebagian besar pasien adalah laki-laki, sesuai dengan penelitian Cogulu dkk 3 dan Park dkk. 12 Dari berbagai penelitian sebelumnya, insiden kasus infeksi menurun sejalan dengan bertambahnya usia. Kelompok usia pasien di bawah usia 2 tahun 46%, usia di atas 2 tahun sampai 6 tahun 35% dan usia di atas 6 tahun 19%, sejalan dengan penelitian dari Pizzo dkk, 6 Cogulu dkk, 3 Han dkk, 13 serta Chiang dkk.…”

Section: Pembahasanunclassified

Etiologi dan Karakteristik Demam Berkepanjangan pada Anak di RS Dr. Cipto Mangunkusumo Jakarta

Bakry

Tumbelaka

2016

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A Prospective Study of Clinico-Aetiological Profile of Fever of Unknown Origin in Children Admitted to a Tertiary Care Center

Nalli¹,

Velampalli²,

Borigama³

2020

jebmh

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Investigation of causes of FUO (fever of unknown origin) in children

Cited by 4 publications

References 16 publications

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Etiologi dan Karakteristik Demam Berkepanjangan pada Anak di RS Dr. Cipto Mangunkusumo Jakarta

A Prospective Study of Clinico-Aetiological Profile of Fever of Unknown Origin in Children Admitted to a Tertiary Care Center

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