Investigation of cannabidiol gastro retentive tablets based on regional absorption of cannabinoids in rats

Izgelov, Dvora; Freidman, M.; Hoffman, Amnon

doi:10.1016/j.ejpb.2020.05.010

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…The suggested formulation examined in vitro was a floating gastro-retentive tablet based on egg albumin matrix, gas-generating agents, and surfactants. In vivo investigation of CBD-containing formulations in a freely moving rat model showed a prolonged absorption phase with a substantial increase in bioavailability compared to the CBD solution [ 95 ]. Izgelov et al (2020) investigated the oral absorption processes of synthetic CBD administered in different oral formulations (oils or oil-based solutions) in 12 healthy male volunteers.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

et al. 2023

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Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases.

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Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

et al. 2023

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“…Multiple preclinical models were used to assess the pharmacokinetics of cannabinoids: rats, mice, dogs, rhesus monkeys, guinea pigs, rabbits, and pigs ( Pryor et al, 1977 ; Chiang et al, 1983 ; Perlin et al, 1985 ; Leuschner et al, 1986 ; Samara et al, 1988 ; Samara et al, 1990 ; Bornheim et al, 1995 ; Mannila et al, 2004 ; Valiveti and Stinchcomb, 2004 ; Brunet et al, 2006 ; Mannila et al, 2006 ; Valiveti et al, 2007 ; Paudel et al, 2010 ; Al-Ghananeem et al, 2011 ; Hasiwa et al, 2011 ; Deiana et al, 2012 ; Ginsburg et al, 2014 ; Zgair et al, 2015 ; Cherniakov et al, 2017b ; Hlozek et al, 2017 ; Bartner et al, 2018 ; Ravula et al, 2018 ; Elmes et al, 2019 ; Fuchs et al, 2019 ; Xu et al, 2019 ; Łebkowska-Wieruszewska et al, 2019 ; Izgelov et al, 2020a ; Izgelov et al, 2020b ; Izgelov et al, 2020c ; Fernández-Trapero et al, 2020 ; Itin et al, 2020 ; Torrens et al, 2020 ; Uziel et al, 2020 ; Michael, 2021 ). Pharmacokinetics parameters of THC, 11-OH-THC, THC-COOH, THCV, CBD, CBDV and CBG are presented in Table 3 after different modes of administration.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of Cannabis and Its Derivatives in Animals and Humans During Pregnancy and Breastfeeding

et al. 2022

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Cannabis is one of the most widely used illicit drugs during pregnancy and lactation. With the recent legalization of cannabis in many countries, health professionals are increasingly exposed to pregnant and breastfeeding women who are consuming cannabis on a regular basis as a solution for depression, anxiety, nausea, and pain. Cannabis consumption during pregnancy can induce negative birth outcomes such as reduced birth weight and increased risk of prematurity and admission to the neonatal intensive care unit. Yet, limited information is available regarding the pharmacokinetics of cannabis in the fetus and newborn exposed during pregnancy and lactation. Indeed, the official recommendations regarding the use of cannabis during these two critical development periods lack robust pharmacokinetics data and make it difficult for health professionals to guide their patients. Many clinical studies are currently evaluating the effects of cannabis on the brain development and base their groups mostly on questionnaires. These studies should be associated with pharmacokinetics studies to assess correlations between the infant brain development and the exposure to cannabis during pregnancy and breastfeeding. Our project aims to review the available data on the pharmacokinetics of cannabinoids in adults, neonates, and animals. If the available literature is abundant in adult humans and animals, there is still a lack of published data on the exposure of pregnant and lactating women and neonates. However, some of the published information causes concerns on the exposure and the potential effects of cannabis on fetuses and neonates. The safety of cannabis use for non-medical purpose during pregnancy and breastfeeding needs to be further characterized with proper pharmacokinetic studies in humans feasible in regions where cannabis has been legalized. Given the available data, significant transfer occurs to the fetus and the breastfed newborn with a theoretical risk of accumulation of products known to be biologically active.

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“…Once administered to rats, the gastro-retentive dosage form showed a prolonged absorption phase with a substantial increase in bioavailability, compared to the CBD-lipid formulation, thanks to gradual drug release. Indeed, dissolution into the aqueous environment of the stomach is a rate limiting step for CBD, but when it occurs under sink conditions, the absorption is less dependent on this process [ 149 ].…”

Section: Pharmaceutical-grade Cannabinoid Formulationsmentioning

confidence: 99%

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Stella

Baratta

Pepa

et al. 2021

Drugs

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The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests that phytocannabinoids are beneficial for a range of conditions. At the same time impressing development has been observed for formulations and delivery systems expanding the potential use of cannabinoids as an effective medical therapy. The objective of this review is to present the most recent results from pharmaceutical companies and research groups investigating methods to improve cannabinoid bioavailability and to clearly establish its therapeutic efficacy, dose ranges, safety and also improve the patient compliance. Particular focus is the application of cannabinoids in pain treatment, describing the principal cannabinoids employed, the most promising delivery systems for each administration routes and updating the clinical evaluations. To offer the reader a wider view, this review discusses the formulation starting from galenic preparation up to nanotechnology approaches, showing advantages, limits, requirements needed. Furthermore, the most recent clinical data and meta-analysis for cannabinoids used in different pain management are summarized, evaluating their real effectiveness, in order also to spare opioids and improve patients’ quality of life. Promising evidence for pain treatments and for other important pathologies are also reviewed as likely future directions for cannabinoids formulations.

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Investigation of cannabidiol gastro retentive tablets based on regional absorption of cannabinoids in rats

Cited by 12 publications

References 31 publications

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

Pharmacokinetics of Cannabis and Its Derivatives in Animals and Humans During Pregnancy and Breastfeeding

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

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