Investigation of cancer incidence in ELSA-Brasil

Moreira, Alexandra Dias; Teles de Menezes, Sara; Júnior, Munir Murad; da Silva Vicente, Jefferson Tennesse; Camelo, Lidyane V.; Barreto, Sandhi Maria

doi:10.1016/j.canep.2023.102467

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…The heterogeneity of our sample, including patients from various age groups, may limit the study’s external validity. However, this aspect mirrors the demographic profile of the Brazilian population affected by the disease 37 , which is a strength. Third, we did not account for differences in BC based on the location of colon cancer (right or left).…”

Section: Discussionmentioning

confidence: 92%

Examining variations in body composition among patients with colorectal cancer according to site and disease stage

da Silva Nascimento,

Alves Bennemann,

de Sousa

et al. 2024

Sci Rep

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Patients with colorectal cancer (CRC) often exhibit changes in body composition (BC) which are associated with poorer clinical outcomes. Many studies group colon and rectal cancers together, irrespective of staging, potentially affecting assessment and treatment strategies. Our study aimed to compare BC in patients with CRC focusing on tumor location and metastasis presence. A total of 635 individuals were evaluated, with a mean age of 61.8 ± 12.4 years and 50.2% female. The majority had rectal cancer as the primary cancer site (51.0%), and 23.6% had metastatic disease. The first regression model showed tumor site and metastasis as independent factors influencing skeletal muscle (SM), skeletal muscle index (SMI), and visceral adipose tissue variability (all p values < 0.05). The second model, adjusted for BMI, indicated tumor site as the primary factor affecting SMI variations (adjusted R2 = 0.50 p < 0.001), with colon tumors inversely associated with SM (standardized β − 2.15(− 3.3; − 0.9) p < 0.001). A third model, considering all the confounders from the directed acyclic graphs, was constructed and the found association remained independent. Our findings highlight significant BC variations in patients with CRC, influenced by tumor location and metastases presence, underscoring the need for location-specific assessment in CRC management.

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Section: Discussionmentioning

confidence: 92%