Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer

Cheung, Min Rex; Tucker, Susan L.; Dong, Lei; Crevoisier, R. de; Lee, Andrew K.; Frank, Steven J.; Kudchadker, Rajat J.; Thames, Howard D.; Mohan, Radhe; Kuban, Deborah A.

doi:10.1016/j.ijrobp.2006.10.042

Cited by 126 publications

(101 citation statements)

References 35 publications

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“…The impact of smoking has previously been found for rectal toxicity associated with amplified vascular damage, tissue hypoxia and fibrosis [37]. PC1, which was significantly associated with urinary frequency, is correlated to the mean dose suggesting the importance of global dose distribution for this endpoint as opposed to maximum dose frequently suggested to play a bigger role in causation of urinary symptoms [3,4]. Radiotherapy has been associated with reduction in bladder capacity and decrease in bladder volume at first sensation [38].…”

Section: Discussionmentioning

confidence: 95%

“…Combination of different symptoms into grades (e.g. RTOG scale as in [3,9,11,12]) has the potential to obscure relevant associations if individual symptoms have different pathophysiological origins, thus, symptoms were atomised. We indeed found several factors which were influencing a specific urinary symptom and not others, facilitating a more symptom-specific pathophysiological understanding.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the dosimetric factors [3][4][5][6], urinary symptoms have been demonstrated to be influenced by other comorbidities, including hypertension [7,8], diabetes [9,10] and baseline urinary symptoms [11,12]. There are suggestions that the intake of certain medications related has an impact on the interaction between radiation treatment and biological systems, which influences the expression of symptoms [10,13].…”

Section: Introductionmentioning

confidence: 99%

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Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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Urinary symptoms (frequency, incontinence, dysuria and haematuria) were prospectively assessed using LENT-SOMA to a median of 72 months. The endpoints assessed were prevalence (grade≥1) at the end of radiotherapy (representing acute symptoms), at 18-, 36-and 54-month follow-ups (representing late symptoms) and peak late incidence including only grade≥2. Impact of factors were assessed using multivariate logistic regression models with correction for over-optimism. Results: Baseline symptoms, non-insulin dependent diabetes mellitus, age and PC1 (correlated to the mean dose) impact symptoms at >1 timepoints. Associations at a single timepoint were found for cerebrovascular condition, ECOG status and non-steroidal anti-inflammatory drug intake. Peak incidence analysis shows the impact of baseline, bowel and cerebrovascular condition and smoking status. Conclusions:The prevalence and incidence analysis provide a complementary view for urinary symptom prediction. Sustained impacts across time points were found for several factors while some associations were not repeated at different time points suggesting poorer or transient impact.4

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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“…Grad 2 GÜ yan etki üç ol- Tedavi sırasında mesane doluluğundaki günlük farklılık mesaneye verilen esas dozun hesaplanmasını zorlaştırdığından dolayı; mesane hazırlık protokolüyle planlama ile nispeten uyumlu mesane volümü ile hastalarımızın tedaviye alınması sağlanmıştır. [31] Ayrıca, çalışmalarda, radyoterapi planlama öncesi ve radyoterapi boyunca lif ve laktoz kısıtlı yiyeceklerden oluşan diyet ile Gİ yan etkilerin azaltılabildiği gösterilmiştir. [32] Pettersson ve ark.…”

Section: Discussionunclassified

Acute toxicity in prostate carcinoma patients treated with kV-CBCT guided IMRT/VMAT

Özdemir¹

2014

TJ Oncol

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obJecTIveSTo evaluate acute toxicity of image guided IMRT/VMAT in prostate carcinoma patients. MeTHodSAcute toxicities of 101 prostate carcinoma patients, treated with radical radiotherapy were evaluated. Prostate, prostate and seminal vesicles, and pelvic lymph nodes were enrolled into the treatment volume in 50, 40 and 11cases respectively. All patients were planned with Eclipse treatment planning system using dynamic IMRT/ VMAT. The median doses to the planning target volumes of prostate, seminal vesicles and pelvic lymphatics were 76Gy, 56Gy and 54Gy respectively, delivered simultaneously. All patients were observed per week during radiotherapy and at 1st and 3rd month following completion of therapy. Acute toxicities were graded according to the RTOG scoring criteria. reSULTSGrade 2 and 1genitourinary acute toxicity were observed in 3 and 57 patients, respectively. Grade1 gastrointestinal toxicity was detected in 15 patients, 3 patients developed grade1 skin reaction. Grade 1 leukopenia was detected in 2 cases. No grade 3-4 toxicity was observed. coNcLUSIoNIn prostate cancer, higher doses radiotherapy with kV-CBCT guided IMRT/VMAT technique was given more accurately and well tolerated. Expected side effects depending on size of irradiated volume with pelvic radiotherapy, were not observed.

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“…The study of Cheung et al [16] that uses the hot-spot model shown that the dose received ≥ 78 Gy to the hottest 50% of bladder developed GU complication (p = 0.002) compared to 25% of the patients who received < 78 Gy to the hottest 2.9% of bladder experienced late GU complication after 8 years. Their results also showed that the patients with late GU events within 2 years seem to have a significant association at about 78 Gy on the differential DVHs.…”

Section: Gu Complicationmentioning

confidence: 99%

Radiation-induced complications in prostate cancer patients treated with radiotherapy

Azuddin

Rahman²,

Siah

et al. 2014

AIP Conference Proceedings

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Abstract. The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60 rectum , rectal mean dose and NTCP rectum with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.

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Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer

Cited by 126 publications

References 35 publications

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Acute toxicity in prostate carcinoma patients treated with kV-CBCT guided IMRT/VMAT

Radiation-induced complications in prostate cancer patients treated with radiotherapy

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