Investigation of bioaccessibility of Cu, Fe, Mn, and Zn in market vegetables in the colon using PBET combined with SHIME

Yin, Naiyi; Cai, Xiaolin; Chen, Xiaochen; Du, Hongwang; Xu, Jiayan; Wang, Lihong; Sun, Guoxin

doi:10.1038/s41598-017-17901-1

Cited by 27 publications

(8 citation statements)

References 37 publications

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“…Therefore, in 60 s milled samples increased trend was observed as variation in the available soluble fraction of Zn is minimized. Zinc bioaccessibility of 19.9-63.7% were reported in the vegetables like lettuce, pak choi, cole, and leaf lettuce (Yin et al 2017) which is under the range of % bioaccessibility of the present study.…”

Section: Resultssupporting

confidence: 45%

Studies on in vitro bioavailability and starch hydrolysis in zinc fortified ready-to-eat parboiled rice (komal chawal)

et al. 2019

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Zinc fortified parboiled rice (komal chawal) was produced from a low amylose variety of rice by applying 'brown rice parboiling' method. In addition to the effect of milling on fortification, the effectiveness of fortification upon the amount of bioaccessible (in vitro digest) and bioavailable (cellular uptake) form of Zn was tested. The effect on glycaemic index was also assessed by employing an in vitro starch hydrolysis assay. The bioaccessible form of Zn in the unmilled fortified rice were ranged in between 4.24 and 11.07 mg/100 g, which was significantly higher (p \ 0.05) than the milled and unfortified parboiled rice. Similarly, the % absorption of bioavailable Zn was negligible in the unfortified parboiled rice as compared to the fortified rice (14.5-24.5%). The estimated GI of fortified parboiled rice samples was in the range of 50.97-59.79, which was lower than the unfortified parboiled rice (58.80-62.53) and raw rice (78.71-84.64). The results thus demonstrated that Zn fortified komal chawal can be a novel and rapidly produced micronutrient enhanced ready-to-eat rice.

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Section: Resultssupporting

confidence: 45%

Studies on in vitro bioavailability and starch hydrolysis in zinc fortified ready-to-eat parboiled rice (komal chawal)

et al. 2019

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“…However, an insufficient dietary intake of Zn suggests the role of gut microbiota in this function, with the composition of the gut microbiota possibly affecting Zn absorption [126]. In vitro studies have indicated that the bioaccessibility of Zn from vegetables is mainly influenced by the microbiota of the colon [103,127]. However, the lower impact of the human gut microbiota on the bioaccessibility and bioavailability of elemental Zn from vegetables might be attributable to the bioaccessibility of Zn being higher in the small intestinal phase [103].…”

Section: Association Between Zinc and Gut Microbiotamentioning

confidence: 99%

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bielik

Kolísek

2021

IJMS

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Adequate amounts of a wide range of micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient to meet these micronutrient requirements. Mineral deficiency does not seem to be the result of a physically active life or of athletic training but is more likely to arise from disturbances in the quality and quantity of ingested food. The lack of some minerals in the body appears to be symbolic of the modern era reflecting either the excessive intake of empty calories or a negative energy balance from drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary micronutrient availability and microbial composition in the gut. However, the influence of human gut microbiota on the bioaccessibility and bioavailability of trace elements in human food has rarely been studied. Bacteria play a role by effecting mineral bioavailability and bioaccessibility, which are further increased through the fermentation of cereals and the soaking and germination of crops. Moreover, probiotics have a positive effect on iron, calcium, selenium, and zinc in relation to gut microbiome composition and metabolism. The current literature reveals the beneficial effects of bacteria on mineral bioaccessibility and bioavailability in supporting both the human gut microbiome and overall health. This review focuses on interactions between the gut microbiota and several minerals in sport nutrition, as related to a physically active lifestyle.

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“…However, in both the germ-free and conventional mice the presence of bacteria is accompanied with increased expression of CTR1, indicating the presence of bacteria inhibiting the IECs access to extracellular Cu. To further support this notion, an in vitro study determined the bioavailability of Cu to Caco-2 cells after incubation with fecal bacteria and revealed a sharp decrease in the proportion of Cu available for uptake in the cells in the presence of bacteria (42). The microbial composition of fecal bacteria is different from that found in the proximal colon (43), but both bacterial populations, as well as a single strain of bacteria, trigger a physiological response in the Cu metabolism in the GI tract.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice

Miller

Vicentini

Hirota

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Copper is a critical enzyme cofactor in the body but also a potent cellular toxin when intracellularly unbound. Thus, there is a delicate balance of intracellular copper, maintained by a series of complex interactions between the metal and specific copper transport and binding proteins. The gastrointestinal (GI) tract is the primary site of copper entry into the body and there has been considerable progress in understanding the intricacies of copper metabolism in this region. The GI tract is also host to diverse bacterial populations, and their role in copper metabolism is not well understood. In this study, we compared the isotopic fractionation of copper in the GI tract of mice with intestinal microbiota significantly depleted by antibiotic treatment to that in mice not receiving such treatment. We demonstrated variability in copper isotopic composition along the length of the gut. A significant difference, ∼1.0‰, in copper isotope abundances was measured in the proximal colon of antibiotic-treated mice. The changes in copper isotopic composition in the colon are accompanied by changes in copper transporters. Both CTR1, a copper importer, and ATP7A, a copper transporter across membranes, were significantly down-regulated in the colon of antibiotic-treated mice. This study demonstrated that isotope abundance measurements of metals can be used as an indicator of changes in metabolic processes in vivo. These measurements revealed a host–microbial interaction in the GI tract involved in the regulation of copper transport.

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Investigation of bioaccessibility of Cu, Fe, Mn, and Zn in market vegetables in the colon using PBET combined with SHIME

Cited by 27 publications

References 37 publications

Studies on in vitro bioavailability and starch hydrolysis in zinc fortified ready-to-eat parboiled rice (komal chawal)

Studies on in vitro bioavailability and starch hydrolysis in zinc fortified ready-to-eat parboiled rice (komal chawal)

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice

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