Abstract:The integrity of the genetic information is constantly threatened by oxidized agents. 7,8-Dihydro-8-oxoguanine (8-oxo-G) is the most common form of oxidative DNA damage. The accumulation of oxidized bases has associated with numerous diseases and cancers. The properties of oxidized base pairs containing 8-oxo-G were investigated by quantum mechanics methods. In this paper all model molecular structures were optimized by B3LYP/6-31+G* method, the frequency calculations are carried out to confirm that all the st… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.