With the rapid development of transportation infrastructure construction, tunnels, serving as key channels through complex terrains such as mountainous regions and rivers, are confronted with numerous challenges during design and construction phases. Particularly, in tunnel projects with sharp curves, traditional design methods, lacking in-depth analysis of fluid-structure interaction (FSI) effects under navigation conditions, struggle to ensure the long-term safety and stability of tunnels. This study systematically investigates the FSI issues in sharp-curve tunnel sections under navigation conditions through numerical simulation and optimization, aiming to enhance the scientific and practical aspects of tunnel design. Initially, a numerical model suitable for the FSI analysis of sharp-curve tunnel sections was established, capable of simulating the complex interplay between fluid dynamics and tunnel structures. The forces exerted by the fluid on the tunnel structure and its dynamic response characteristics were analyzed in detail through the calculation of coupled fields of fluid dynamics and structural mechanics. Subsequently, the impact of dynamic response parameters of tunnel structures on overall performance was explored using global sensitivity analysis methods. Finally, based on multi-objective optimization theory, the design parameters of tunnel structures were optimized to achieve higher safety and economic efficiency. The methodologies and findings of this article hold significant theoretical value for the design of sharp-curve tunnel sections and provide a reliable analysis and optimization tool for similar complex engineering problems. Practical outcomes indicate that this research significantly enhances the performance of tunnel design, playing a substantial role in ensuring the safe operation of tunnel projects.