Investigation of associations between ABO blood groups and coagulation, fibrinolysis, total lipids, cholesterol, and triglycerides

Abstract

To investigate possible associations between ABO blood system and coagulability levels, fibrinolysis, total lipids, cholesterol, and triglycerides, the plasma and serum of 300 Rh-positive male blood donors were tested. The tests performed were: RT, PTT, K-PTT, PT, F.V, F.II, F.VII, Complex II, VII, and X, TGT, fibrinogen, HAE 0.2, HAE 0.5, ELT, LIP, Col.1, Col.2 and TRI. Analysis of the laboratory data shows a lower coagulability in O blood group individuals. This result was obtained in coagulation tests (RT, PTT, and K-PTT) specific for factor VIII level. In addition, a higher sensitivity to the in vitro heparin anticoagulant effect in O group individuals was confirmed. Nevertheless, these conclusions are specific for Negroids, the same effects not being observed in Caucasians. None of the other laboratory tests revealed any differences related to either blood group or race.

Population differences in von Willebrand factor levels affect the diagnosis of von Willebrand disease in African‐American women

“…The finding of higher levels of vWF:Ag and FVIII in African-American women than in Caucasians confirms results from previous American studies [8,9]. Similar observations have been made in other populations of African descent in Britain [14,15], Brazil [16], and South Africa [17]. The worldwide distribution of these differences suggests that they are part of the genetic diversity that characterizes racial groups.…”

ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage

“…Type-O blood is associated with both increased bleeding and activated partial thromboplastin times, measures of overall coagulation and the extrinsic coagulation pathway, respectively [19]. This reflects a reduction in circulating levels of factor VIII and von Willebrand factor, components of the intrinsic coagulation pathway.…”

ABO(H) blood groups and vascular disease: a systematic review and meta‐analysis

“…AA, AB and BB) [1]. Although ABO(H) may also influence activated protein C resistance [2], no consistent relationship with cholesterol [3,4] or other coagulation markers [4–7] has been proven. Thus, estimating whether the strength of association between ABO(H) type and thrombosis is similar to that predicted by the known relationship between VWF/FVIIIc levels and disease would add considerable weight to the hypothesis that these factors are causal.…”