Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort

Indhumathi, S; Rajappa, Medha; Chandrashekar, Laxmisha; Ananthanarayanan, Palghat Hariharan; Thappa, Devinder Mohan; Negi, Vir Singh

doi:10.1016/j.humimm.2015.10.006

Cited by 16 publications

(14 citation statements)

References 43 publications

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“…In PsA, treatment with anti‐IL‐23 antibodies have shown beneficial effects but not in RA so far. Another finding supporting this hypothesis, is the notion that polymorphisms in the IL‐23 receptor (IL‐23R) have been linked to susceptibility for psoriasis and PsA , but are still a matter of debate in RA (Table ) .…”

Section: Introductionmentioning

confidence: 97%

The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling

2018

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The IL‐23/Th17 axis has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). RA and PsA are heterogeneous diseases with substantial burden on patients. Increasing evidence suggests that the IL‐23 signaling pathway may be involved in the development of autoimmunity and erosive joint damage. IL‐23 can act either directly or indirectly on bone forming osteoblasts as well as on bone resorbing osteoclasts. As IL‐23 regulates the activity of cells of the bone, it is conceivable that in addition to inflammation‐mediated joint erosion, IL‐23 may play a role in physiological bone remodeling. In this review, we focus on the role of IL‐23 in autoimmune arthritis in patients and murine models, and provide an overview of IL‐23 producing and responding cells in autoimmune arthritic joints. In addition, we discuss the role of IL‐23 on bone forming osteoblasts and bone resorbing osteoclasts regarding inflammation‐mediated joint damage and bone remodeling. At last, we briefly discuss the clinical implications of targeting this pathway for joint damage and systemic bone loss in autoimmune arthritis.

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Section: Introductionmentioning

confidence: 97%

The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling

2018

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“…Genome-wide association studies have also identified several psoriasis-related chromosomal regions such as the receptors for interleukin 23 (IL-23) and IL-12B [ 14 , 15 ]. The results of the Indhumathi study suggest that the variants of IL-12B (rs3212227) and IL-23R (rs2201841) genes are related to an increased risk of developing Ps in the ethnic South Indian Tamils population [ 16 ]. A meta-analysis of 997 Ps cases and 943 control subjects for –238G>A and of 1,156 psoriasis cases and 1,083 control subjects for –308G>A polymorphism of the TNF gene showed that a significantly increased risk was associated with the variant –238G>A and GA + AA genotypes, compared with the GG genotype, whereas the GA + AA genotypes in position –308G>A were correlated with a reduced psoriasis risk.…”

Section: Personalized Therapy In Psoriasismentioning

confidence: 99%

Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future

Osmola‐Mańkowska¹,

Teresiak-Mikołajczak²,

Skrzypczak-Zielińska³

et al. 2018

pdia

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The concept of personalized medicine is a new individualized approach which helps application of the targeted therapy. In fact, tailored medicine is mostly present in the field of life-threatening diseases such as oncology. However, skin diseases as such might be regarded as a potential area of implementation of this approach in the future. Stratified medicine in polygenetic and heterogeneous diseases, such as psoriasis, is more complex. Rapid development of science and novel molecular techniques led to better understanding of molecular pathogenetic pathways of many diseases including psoriasis. Identification of the particular immunopathogenetic pathways led to further development of targeted therapies such as biologic drugs. Actually the goal of individualized therapy is to determine the identical homogenous subgroups of patients, according to a biomarker, in which the response to that therapy will be the best and will carry the lowest risk of side effects. This review attempts to analyze the associations between polymorphisms of certain genes and the increased risk of developing psoriasis or psoriatic arthritis. The review of literature has also included the studies investigating the associations between gene polymorphisms and response to biologic therapy in psoriasis and psoriatic arthritis patients.

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“…gematchte gesunde Kontrollpersonen wurden für die vorliegende Fall-Kontroll-Studie aus einer größeren krankenhausbasierten Kohorte rekrutiert [3]…”

Section: Clinical Letterunclassified

Genpolymorphismen proinflammatorischer Zytokine aus Th1‐Zellen und das Psoriasisrisiko in einer südindischen tamilischen Kohorte

Indhumathi

Rajappa

Chandrashekar

et al. 2017

J Deutsche Derma Gesell

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Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort

Cited by 16 publications

References 43 publications

The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling

The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling

Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future

Genpolymorphismen proinflammatorischer Zytokine aus Th1‐Zellen und das Psoriasisrisiko in einer südindischen tamilischen Kohorte

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