Investigation of Area under the Curves for Insulin Secretion in Diabetes

Bando, Hiroshi; Ebe, Koji; Muneta, Tetsuo; Bando, Masahiro; Yasuda, Yoshikazu

doi:10.18689/ijbr-1000105

Cited by 5 publications

(6 citation statements)

References 22 publications

(28 reference statements)

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“…Therefore, we analyzed AUC and ⊿AUC for glucose and IRI during 0-2h and analyzed several related data [23]. The result showed that the obtained distribution of M value was wider than the distribution of mean blood glucose, and then the difference can be clearly grasped [24]. In this way, even if the levels of HbA1c and mean blood glucose are nearly the same in many diabetic cases, the M value level could be clinically useful for detecting unstable glucose variability such as larger MAGE [17].…”

Section: Discussionmentioning

confidence: 98%

“…The result showed the intersection of case D and case F (Fig- 3b), where the relative difference seemed to exist between the total area of IGI and the area of ⊿IGI. In previous studies, elder patients tended to show slower glucose and IRI responses with higher IRI values and glucose 2 hours after a meal [24]. Therefore, we analyzed AUC and ⊿AUC for glucose and IRI during 0-2h and analyzed several related data [23].…”

Section: Discussionmentioning

confidence: 99%

“…The latter means the comparison of the total AUC of glucose and IRI. It is expressed as AUC Ratio of IGI for 2 hours, which can be calculated as (AUC-IRI for 0-2 hours) (μU/mL x h)/ (AUC-glucose for 0-2 hours) (mg/dL x h) [24].…”

Section: Auc Studymentioning

confidence: 99%

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Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

Takehisa¹,

Bando

2020

Diab Res Open Access

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Background: Authors and collaborators have continued medical practice in the Heisei Medical Welfare (HMW) group for long years for mainly two areas, extensive care for the elderly and diabetes research. From both of them, the current research was held on the daily profile of glucose and insulin for patients with type 2 diabetes mellitus (T2DM). Subjects and Methods: Cases were 6 T2DM patients in admission, with ages 67.5 ± 12.7 years, diabetes duration 9.5 years. Methods included a daily profile of glucose and insulin for seven times per day, Morbus (M) value, Meal Tolerance Test (MTT) using breakfast with 70g carbohydrate, insulinogenic index (IGI)-2 hours, various correlations among HbA1c, M value, Area Under the Curve (AUC) of glucose and insulin. Results: Cases showed average values of HbA1c 8.4 ± 0.7%, glucose 197 mg/dL, M value 111. Glucose and IRI levels increased during 0700-0900h with 154-258 mg/dL and 13.8-54.3 μU/ml. There was a significant correlation between Glucose-⊿AUC and M value (p<0.05). Discussion: Daily profile of glucose and insulin showed a similar manner, suggesting post-prandial glucose influence due to carbohydrate intake. When studied cases increase, significant correlations among M value, HbA1c and glucose-AUC seem to be found. This report hopefully becomes a reference for future diabetic research.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

Takehisa¹,

Bando

2020

Diab Res Open Access

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“…We previously investigated AUC for insulin secretion in diabetes [30]. Carbo70 loading was performed on 42 cases of T2DM, and the insulin response was examined in 0 to 30 minutes.…”

Section: Discussionmentioning

confidence: 99%

A Trial of Analysis Method for Insulin Secretion Response to Carbohydrate Loading

Bando

Ebe²,

Hashimoto

et al. 2020

EJBMR

Self Cite

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Authors et al. have continued diabetic practice and research for long, and started Low Carbohydrate Diet (LCD) first in Japan. We developed social LCD movement by Japanese LCD Promotion Association (JLCDPA), and proposed petite-, standard-, super LCDs with carbohydrate 40%, 26%, 12%, respectively. Methods included 9 healthy medical staffs and two exams of 75g Oral Glucose Tolerance Test (OGTT) and Meal Tolerance Test (MTT). MTT means super-LCD breakfast with carbohydrate 6g. Results showed that blood glucose / immunoreactive insulin (IRI) at 0-30 min on average changed 88.0-130.6 mg/dL/5.1-46.5 μU/mL for GTT, and 90.1-86.3 mg/dL/4.8-12.5 μU/mL for MTT. IRI responses in GTT and MTT were calculated by 3 methods, which are i) increment (delta), ii) Area Under the Curves (AUC), iii) Multiple (times) of basal value. Both data from GTT and MTT showed significant correlation in i) and ii) (p<0.05), but not significant in iii) (p=0.07, n=9). These results suggested that insulin secretion in MTT would be enough and relatively excessive for 6g of carbohydrate, leading to relatively decreased glucose at 30 min. Current analyses methods will become some reference for future development of diabetic research.

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“…Our group investigators have clarified the physiological beneficial role from hyperketonemia in the axis of a pregnant mother, newborn, placenta and fetus [12]. Furthermore, a comparison of the daily profile of glucose variability on CR and LCD has investigated, and CR breakfast with 70g of carbohydrate has been utilized for meal tolerance test (MTT) similar to 75gOGTT [13,14].…”

Section: Introductionmentioning

confidence: 99%

SGLT2 inhibitors

2020

Diab Res Open Access

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Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research.

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Investigation of Area under the Curves for Insulin Secretion in Diabetes

Cited by 5 publications

References 22 publications

Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

A Trial of Analysis Method for Insulin Secretion Response to Carbohydrate Loading

SGLT2 inhibitors

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