2018
DOI: 10.24953/turkjped.2018.05.007
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Investigation of antiviral resistance and escape mutations in children with naive chronic hepatitis B patients and their parents

Abstract: Tokgöz Y, Terlemez S, Sayan M, Kırdar S. Investigation of antiviral resistance and escape mutations in children with naive chronic hepatitis B patients and their parents. Turk J Pediatr 2018; 60: 514-519. In this study, it was aimed to scan the resistance to nucleoside analogs in naive pediatric patients with chronic hepatitis B treatment and their parents and the rate of accompanying possible escape mutations. A total of 34 children who did not receive any treatment regarding chronic hepati… Show more

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“…These mutations in addition to sT57I, sQ101H, sG130R, sY134F, and sL216stop could alter the antigenicity of HBsAg and reduce its expression and/or recognition by antibodies. Therefore, they could induce immune, vaccine, HBIG therapy, and/or diagnosis escape as well as influence HBsAg expression and treatment efficacy ( Moerman et al, 2004 ; Sitnik et al, 2004 ; Bahramali et al, 2008 ; Amini-Bavil-Olyaee et al, 2010 ; Coppola, 2015 ; Ziaee et al, 2016 ; Rendon et al, 2017 ; Tokgöz et al, 2018 ; Aydın et al, 2019 ; Hosseini et al, 2019 ; Duda, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…These mutations in addition to sT57I, sQ101H, sG130R, sY134F, and sL216stop could alter the antigenicity of HBsAg and reduce its expression and/or recognition by antibodies. Therefore, they could induce immune, vaccine, HBIG therapy, and/or diagnosis escape as well as influence HBsAg expression and treatment efficacy ( Moerman et al, 2004 ; Sitnik et al, 2004 ; Bahramali et al, 2008 ; Amini-Bavil-Olyaee et al, 2010 ; Coppola, 2015 ; Ziaee et al, 2016 ; Rendon et al, 2017 ; Tokgöz et al, 2018 ; Aydın et al, 2019 ; Hosseini et al, 2019 ; Duda, 2020 ).…”
Section: Discussionmentioning
confidence: 99%