Investigation of antiulcer activity of the thick extract of immature walnut fruits on the model of diclofenac-reduced gastric ulcer of rats

Zalygina, Ye. V.; Podpletnya, O. A.

doi:10.14739/2409-2932.2017.3.113620

Cited by 2 publications

(1 citation statement)

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“…Medicinal plants have been widely used in the treatment of many diseases, and nowadays it is difficult to overestimate the importance of herbal medicines for medical practice [1,2]. These drugs are especially important in the field of gastroenterology, given that used in clinical practice, synthetic antiulcer drugs often lead to the development of various side effects and, accordingly, have a large list of contraindications [3,4].…”

Section: Introductionmentioning

confidence: 99%

Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats.

Galuzinska

Кравченко

Kravchenko

et al. 2021

SR: BS

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Medicinal plants have been widely used in the treatment of many diseases, especially in the gastroenterology, given that the use of synthetic antiulcer drugs in clinical practice often leads to the development of various kinds of side effects and, accordingly, have a large list of contraindications. The aim of this experimental work was the study of the antiulcer activity of the food concentrate of phenolic compounds of apples on the models of experimental ulcers in rats. Materials and methods. The studies included two stages, which were carried out on models: stage I – a model of alcohol–prednisolone stomach ulcer in rats, stage II – a model of indomethacin stomach ulcer in rats in accordance with the methodological recommendations of the SEC of the Ministry of Health of Ukraine. The studied concentrate was administered in a dose based on the total content of polyphenols – 9 mg per 100 g of weight. Quercetin at a dose of 5 mg / kg and ranitidine at a dose of 20 mg / kg were used as reference drugs. After replicating the models, a macroscopic examination of the gastric mucosa was carried out and the content of TBA-reactants and reduced glutathione in the stomach homogenate was determined. Results. Under pathological conditions, the therapeutic effect of the food concentrate of phenolic compounds of apples and reference drugs was comparable in terms of the degree of ulcer defect. It was proved that food concentrate of phenolic compounds of apples and reference drugs inhibit the course of lipid peroxidation reactions and support endogenous antioxidant defense systems. Conclusions. The obtained results make it possible to recommend a further study of the food concentrate of phenolic compounds of apples for the creation of a pharmaceutical preparation on its basis. A promising area of application of this concentrate will be the prevention and treatment of gastric ulcer

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Section: Introductionmentioning

confidence: 99%

Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats.

Galuzinska

Кравченко

Kravchenko

et al. 2021

SR: BS

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Investigation of Walnut Herbal Drug Raw Material

Chebyshev

Стреляева

Lezhava

et al. 2019

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Walnut (Juglans regia L.) is a medicinal plant containing a large number of biologically active substances. A number of authors propose to use walnut leaves as medicinal raw materials, in which juglone, flavonoids, tannins, ascorbic acid and other substances are identified. Currently, a standardization technique for this type of raw material has been developed and proposed. However, the medicinal plant walnut can be a source of other types of raw materials, such as milky-waxed walnuts, walnut bark, and walnut partitions. These types of medicinal raw materials contain a large number of biologically active substances and have a great potential for pharmacological activity. Therefore, the study with the subsequent standardization of medicinal plant material of walnut fruits in the stage of milk-wax ripeness and walnut bark is relevant.Aim. The aim of the study is to study the external signs, microscopy of raw walnut bark and walnut fruit in the stage of milky-wax ripeness and chemical composition of alcohol extract from these types of raw materials.Materials and methods. Chromato-mass spectrometry and TLC were used in the work.Results and discussion. When describing external signs and microscopy, diagnostic signs of both whole and crushed raw materials, and powder of walnut bark, and fruits of walnut in the stage of milky-wax ripeness were revealed. Alcohol extract obtained from medicinal plant raw materials walnut bark is a clear brown liquid. Alcohol extract obtained from medicinal plant raw materials of walnut fruit at the stage of milky-wax ripeness is a transparent, green-brown liquid with a fragrant odor.Conclusion. Gallic acid was identified by TLC in walnut bark. Chromato-mass spectrometry in alcohol extraction from the fruit of walnut in the stage of milky-wax maturity was able to identify 17 compounds belonging to different classes of biologically active substances. Sugars, flavonoids, coumarin phenolic compounds, organic acids were identified. In alcoholic extraction from the bark of a walnut, marker compounds have been determined, the combination of which makes it possible to quickly identify this type of raw material using chromatography-mass spectrometry.

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Investigation of antiulcer activity of the thick extract of immature walnut fruits on the model of diclofenac-reduced gastric ulcer of rats

Cited by 2 publications

References 1 publication

Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats.

Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats.

Investigation of Walnut Herbal Drug Raw Material

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