Investigation of antiproliferative mechanisms of Alstonia angustiloba-silver nanoparticles in skin squamous cell carcinoma (A431 cell line)

Rahim, Nurhidayah Ab.; Mail, Mohd Hafiz; Muhamad, Musthahimah; Sapuan, S. M.; Mydin, Rabiatul Basria S. M. N.; Seeni, Azman

doi:10.1016/j.molstruc.2021.131814

Cited by 4 publications

(2 citation statements)

References 87 publications

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“…1 filter paper to obtain a clear filtrate extract solution. The filtrate was then freeze-dried to obtain the powder and stored at −20 °C until further use (Rahim et al, 2022).…”

Section: Preparation Of Ethanol Extractmentioning

confidence: 99%

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Nindatu,

Kaihena,

Hieriej

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Alstonia sp leaves extract has previously been reported as a potential antimalarial drug as traditional. This study aims to analyze the antimalarial activity and determine the antioxidant potential of titi tree leaves (Alstonia sp). The method used in this research is a modified method of "4 Days Suppressive Test" which was originally described by Peter with different doses (0.55 g/kg, 0.65 g/kg and 0.75 g/kg body weight) of methanol extract of leaves of Titi tree (Alstonia sp) was administered orally to albino mice. Antioxidants were analyzed using a spectrophotometer. The Leaves of Alstonia sp has antimalarial activity and contains potential antioxidant activity with an IC50 value of 70.12 ppm for leaves (strong category). The dose of 0.75 g has a better effect compared to the other effects because it lowers the level of parasitemia more strongly. So that the leaves of Alstonia sp. pressured to be developed as a nutraceutical.

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“…1 filter paper to obtain a clear filtrate extract solution. The filtrate was then freeze-dried to obtain the powder and stored at −20 °C until further use (Rahim et al, 2022).…”

Section: Preparation Of Ethanol Extractmentioning

confidence: 99%

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Nindatu,

Kaihena,

Hieriej

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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“…Rahim et al [ 100 ] investigated the biogenic synthesis of Alstonia angustiloba -AgNPs by the aqueous extract of A. angustiloba leaves and evaluated its antiproliferative mechanisms. The cytotoxicity of A. angustiloba aqueous extracts and A. angustiloba -AgNPs were evaluated using the MTT experiment towards the A431 cancer cell line.…”

Section: Nanotechnology (Metallic and Related Nps) Are Significant To...mentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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Understanding the charismatic potential of nanotechnology to treat skin carcinoma

Sathe,

Prajapati,

Bhattacharya

2023

Med Oncol

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Investigation of antiproliferative mechanisms of Alstonia angustiloba-silver nanoparticles in skin squamous cell carcinoma (A431 cell line)

Cited by 4 publications

References 87 publications

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Understanding the charismatic potential of nanotechnology to treat skin carcinoma

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