Investigation of Antioxidant Effect of Zinc Biochemically and Histopathologically in Rats

Abstract

In this study, biochemically (Total anti oxidant capacity (TAC), Alanin aminotransferaz (ALT) ve Aspartat aminotransferaz (AST)) and histopathologically effects investigated inCCl 4 -treated rats and the effects of intraperitoneal zinc administration on these parameters. Cirrhosis was induced in 40 rats by intraperitoneal injections of CCl 4 twice a week over 6 weeks. Forty and ten additional animals were used as controls. Both groups were further subdivided to receive standard diet. TAC, ALT and AST were also worked out. Masson's trichrome stain was applied to evaluate the fibrosis in liver. The results were evaluated by means of Student-t and Mann Whitney U tests in SPSS 6.0. TAC in plasma was significantly different into experimental goups ( P <0.05). Value of TAC was lower in B group than in C and D groups ( P <0.05), however differences between control and A,C,D groups was not important (P> 0.05). It is found out that the TAC in the groups which treated with CCl 4 + ZnSO 4 were higher than the groups those treated with only CCl 4 . This finding support that zinc plays an important role in regeneration of the damaged cells and antioxidant defense mechanism. Moreover, the histopatologic findings of our study were revealed this hypothesis.

Nanocomposites specifically penetrate and inhibit tumor cells

“…It has been shown that the addition of the dye DiI to hybrid nanocomplexes allows the visualization of almost all cells with a CD44 + phenotype in Ehrlich carcinoma cells . This model pathology is a convenient object for experimental studies of the influence of various factors and therapeutic agents directly on cancer cells, as these are undifferentiated cells of in vivo transplanted mice breast cancer .…”

Synthesis, Characterization and in vitro Cytotoxicity Studies of Pentadentate Ligand and its Copper(II) Complexes

“…Dead cells take up the blue colour of trypan blue while live cells do not take up the dye. The number of stained and unstained cells was counted separately [21,22].…”