Investigation of antioxidant activity and lipophilicity parameters of some preservatives

Короткова, Е. И.; Avramchik, O. A.; Angelov, T.; Karbainov, Yu. A.

doi:10.1016/j.electacta.2005.04.031

Cited by 30 publications

(29 citation statements)

References 10 publications

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“…As can be seen, the antioxidative properties of all the parabens investigated are very similar (similar peak potentials of their DPV oxidation curves). Comparable results were obtained by Krotkova et al [18] by a method based on electroreduction of oxygen in the presence of parabens in phosphate buffer solutions.…”

Section: Antioxidative Properties Of Parabenssupporting

confidence: 66%

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Anodic oxidation of parabens in acetic acid–acetonitrile solutions

Michałkiewicz

2012

J Appl Electrochem

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The electrochemical properties of esters of p-hydroxybenzoic acid, called parabens, were investigated on a carbon fiber microelectrode and on a glassy carbon macroelectrode in glacial acetic acid containing 20 % acetonitrile (v/v) and sodium acetate as a supporting electrolyte. The anodic oxidation of parabens in this medium proceeds in a single stage giving well-shaped peaks or waves in the same potential region of above 1.0 V (vs. Ag/AgCl). The electrode process was characterized as being quasireversible, diffusion-controlled, and proceeds with the exchange of one electron and one proton. Phenoxyl radicals as products of the electrode process are chemically unstable and participate in the successive irreversible homogenous reactions resulting in electroinactive products (E q C i mechanism). Smaller oxidation potentials for parabens in comparison to such unsaturated fatty acids as oleic, linoleic, and linolenic ones indicate that these compounds can show antioxidative properties. Since parabens are often used as preservatives in many products, the results presented can be found useful in the determination of their total content in real samples.

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Section: Antioxidative Properties Of Parabenssupporting

confidence: 66%

“…The antimicrobial activity of parabens increases with an increase in the size of the ester group [16,17], which results from the fact that the lipophilicity of these compounds increases in the same direction [17,18]. This property makes it easier for parabens to get thorough the cellular membrane [17].…”

Section: Introductionmentioning

confidence: 98%

Anodic oxidation of parabens in acetic acid–acetonitrile solutions

Michałkiewicz

2012

J Appl Electrochem

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“…Table 1 presents results from the determination of the AOA coefficients of the studied sulfur-containing BAS and standard antioxidants at their most effective concentrations (C = 1´10 -3 M). The standard antioxidants were ascorbic acid, dihydroquercetin, and sodium selenite [16]. Table 1 shows that the BAS exhibited good AOA relative to the standard antioxidants.…”

Section: Resultsmentioning

confidence: 99%

Biologically active substances studied by voltammetric and spectrophotometric techniques

Dorozhko

Короткова

2011

Pharm Chem J

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Sulfur-containing biologically active substances (BAS) demonstrate pronounced antioxidant properties. Glutathione, cysteine, cystine, methionine, taurine, and lipoic acid occupy special positions among sulfur-containing antioxidant compounds. The antioxidant properties of these sulfur-containing BAS have been characterized and analyzed using voltammetric and spectrophotometric data. All studied BAS showed more or less pronounced antioxidant activity. Lipoic acid and glutathione exhibited the maximum antioxidant activity, which agrees with data published in the literature. Methionine showed the minimum antioxidant activity among the group of investigated BAS. The antioxidant activity was compared on the basis of the international criterion of antioxidant properties of sulfur-containing BAS, oxygen radical absorbance capacity (ORAC) with respect to a reference antioxidant (glutathione). A correlation was found between results of the voltammetric and spectrophotometric analyses.

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“…Although, the detection limit of NACE was slightly higher than that of HPLC, both HPLC and NACE methods demonstrated no significant difference in recovery and reproducibility. Compared with the published methods such as GC-MS [6], ion-interaction HPLC [8], and EC [11], the proposed methods in this paper employ a simple mobile phase and electrophoretic solution, which make the determination more simple, economical and accurate. They have been successfully employed to determine BA and SA in real bean samples and gave similar results.…”

Section: Discussionmentioning

confidence: 99%

“…To date, several methods have been developed to assay BA and SA in foodstuffs and cosmetic products, for example, spectrophotometry [3], GC [4,5], GC-MS [6], HPLC [7][8][9][10], electrochemistry (EC) [11], and CE [12]. Among these methods, spectrophotometry and EC methods are subject to matrix interference, which makes the quantification of BA and SA difficult.…”

Section: Introductionmentioning

confidence: 99%

Development of HPLC and NACE methods for the simultaneous determination of benzoic and sorbic acids in sour snap beans containing oil

et al. 2007

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The practical methods were developed for the simultaneous determination of benzoic acid (BA) and sorbic acid (SA) in sour snap bean samples containing oil. BA and SA in the samples were extracted by ultrasonication with water, followed by cleanup procedures with precipitation for removing the potential proteins and with petroleum ether liquid-liquid extraction for removing the edible oil contained in the samples. The HPLC method was developed using Supelco C18 (250 mm x 4.6 mm id, 5 microm) as column, MeOH-20 mM NH(4)Ac (25:75 v/v) at 1.0 mL/min as the mobile phase and 230 nm as the detection wavelength. The optimal NACE method was established with a running buffer of 20.0 mM NH(4)Ac in 95% MeOH (pH* 10.6), and an applied voltage of -30 kV over a capillary of 50 microm id x 48.5 cm (40 cm to the detector window), which gave a baseline separation of BA and SA, and as well as of the blank matrix within ca. 10 min. Both HPLC and NACE methods gave the relatively lower limits of quantification at about 0.01-0.02 and 0.04-0.05 mg/kg, respectively, whereas the overall recoveries were larger than 85.0%. The proposed methods have been successfully applied to measure 15 real sour bean samples and the content profile of BA and SA in sour bean samples was obtained and evaluated.

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Investigation of antioxidant activity and lipophilicity parameters of some preservatives

Cited by 30 publications

References 10 publications

Anodic oxidation of parabens in acetic acid–acetonitrile solutions

Anodic oxidation of parabens in acetic acid–acetonitrile solutions

Biologically active substances studied by voltammetric and spectrophotometric techniques

Development of HPLC and NACE methods for the simultaneous determination of benzoic and sorbic acids in sour snap beans containing oil

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