Investigation of Antimicrobial and Antitubercular Activities of Some Hydrazone Derived Compounds

Abstract

A series of hydrazone derivatives were synthesized to investigate antifungal, antimicrobial and antitubercular activities. These activities were investigated against Escherichia coli, Escherichia coli isolate, Pseudomonas aeruginosa, Pseudomonas aeruginosa isolate (resistant to gentamicin), Staphylococcus aureus, Staphylococcus aureus isolate (MRSA), Enterococcus faecalis, Enterococcus faecalis isolate (VRE), Candida albicans, Candida krusei and Mycobacterium tuberculosis. Among the synthesized compounds B23 had the best activity against Candida albicans with 16 µg/mL MIC value and B24 had the best activity against Staphylococcus aureus isolate (MRSA) with 16 µg/mL MIC value. The most effective compound against Mycobacterium tuberculosis is found to be E9 with 32 µg/mL MIC value, a chalcone derivative. However, all compounds were determined as ineffective against Escherichia coli and Escherichia coli isolate.