Investigation of Antimicrobial and Antioxidant Activities of Tetra-Substituted Phthalocyanines Bearing Tetraethylene Glycol Methyl Ether Chains on Peripheral and Non-Peripheral Positions

Samsunlu, Taylan; Akkoç, Berkay; Özçeşmeci, Mukaddes; Akın, Mustafa; Şaki, Neslihan; Hamuryudan, Esin

doi:10.2139/ssrn.4206811

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“…One of the most widely used ways for assessing the decrease in DPPH radical absorption following exposure to radical scavengers is the measurement of DPPH free radical scavenging activity 31,32 . This activity is widely applicable for the quick determination of antioxidant capacity 33 .…”

Section: Resultsmentioning

confidence: 99%

Investigation of advanced biological properties of carbon, carbon‐boron quantum dots, and copper (II) phthalocyanine nanoconjugates

Özçeşmeci,

Gümrükçü,

Ünlü

et al. 2024

Applied Organom Chemis

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Non‐peripherally, glycerol terminal groups substituted copper (II) phthalocyanine were non‐covalently (electrostatic and/or π–π interaction) attached to carbon (CQD) and carbon‐boron quantum dots (CBQD) to form QDs‐Pc nanoconjugate systems. Synthesized novel phthalocyanine compounds and QDs‐Pc conjugate systems were characterized using different spectroscopic techniques. Various biological assessments were applied to newly synthesized compounds. Conjugates 4 and 5 had a maximal free radical scavenging activity of 71.3% and 68.1% at a 100 mg/L concentration. Compounds exhibited high antidiabetic activities at 200 mg/L. Also, compounds showed significant DNA nuclease activity at all tested concentrations. The most efficient MIC value was obtained as 4 mg/L against Enterococcus hirae and Enterococcus feacalis. This MIC value was further decreased after photodynamic therapy, and it was observed that the antimicrobial effects of the compounds increased. Inhibition of microbial cell viability was obtained as 100% for all compounds. In addition, compounds exerted perfect biofilm inhibitory effects.

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Section: Resultsmentioning

confidence: 99%