Investigation of anti-inflammatory and anti-proliferative activities promoted by photoactivated cationic porphyrin

Carrenho, Luise Zozula Blind; Moreira, Camila Guimarães; Vandresen, Camila Chevonica; Gomes, Rubens; Gonçalves, Alan G.; Barreira, Sandra M. W.; Noseda, Miguel D.; Duarte, Maria Eugênia R.; Ducatti, Diogo R.B.; Dietrich, Michele; Paludo, Kátia Sabrina; Cabrini, Daniela Almeida; Otuki, Michel Fleith

doi:10.1016/j.pdpdt.2015.05.003

Cited by 14 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case at least, no obvious direct antimicrobial effect was observed, since responses to live and heat-killed bacteria were suppressed to the same extent. Similarly, an immunosuppressive effect of a topically applied cationic PS,5,porphyrin was recently reported in a mouse psoriasis model (Carrenho et al 2015). Such PDT diminished several inflammatory indicators, including oedema, proinflammatory cytokine secretion and neutrophil infiltration, and led to reduced keratinocyte proliferation.…”

Section: Pdt-mediated Immune Responses In Non-malignant Applicationsmentioning

confidence: 61%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

View full text Add to dashboard Cite

Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability. Porphyrin-based photosensitisers with amphiphilic properties, bearing one or more positive charges, are an effective tool in PDT against cancers, microbial infections and, most recently, autoimmune skin disorders. The aim of the review is to present some of the recent examples of the applications and research that employ this specific group of photosensitisers. Furthermore, we will highlight the link between their structural characteristics and PDT efficiency, which will be helpful as guidelines for rational design and evaluation of new PSs.

show abstract

Section: Pdt-mediated Immune Responses In Non-malignant Applicationsmentioning

confidence: 61%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

View full text Add to dashboard Cite

show abstract

“…There have so far been few studies demonstrating the clinical efficacy of the use of PDT in the treatment of periodontal disease. [21][22][23] PDT influences periodontal healing and has an antimicrobial effect. 22 A previous study in an experimental rat periodontal disease model with ligature placement showed that PDT-treated animals presented decreased bone resorption, as well as reduced neutrophil migration and lower TNF-a expression.…”

Section: Discussionmentioning

confidence: 99%

“…The successful therapeutic effect of PDT in our case report was possible due to the anti-inflammatory and antiproliferative nature of the therapy. 21 Our PDT protocol for LJSGH was adapted from the protocols used to treat OLP. 17,[26][27][28] Similarly to LJSGH, OLP has an obscure etiology, with an inflammatory nature.…”

Section: Discussionmentioning

confidence: 99%

A Conservative Approach for Localized Spongiotic Gingivitis Hyperplasia Using Photodynamic Therapy: A Case Report and Review of the Literature

Vieira

Leite

Figueiredo

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

View full text Add to dashboard Cite

Objective: To describe a clinical case of successful conservative management of Localized Juvenile Spongiotic Gingivitis Hyperplasia (LJSGH) using photodynamic therapy (PDT) and reviews the current literature on this pathology. Background data: LJSGH is a recently described rare disease with controversial treatment results. As of today, 13 publications report surgical treatment approaches. The use of CO 2 laser and cryotherapy was reported only in one study. The use of PDT was not previously reported. Patients and methods: A 9-year-old male patient was referred to our institution with the chief complaint of asymptomatic ''inflamed gingiva'' starting 1 year before. Clinical examination revealed an erythematous line accompanying the gingival contour, with a certain degree of hyperplasia. The diagnosis of LJSGH was performed based on clinical features and later confirmed histopathologically. A novel approach using PDT was then proposed. The photosensitizer was methylene blue, and a semiconductor laser diode was used. Results: One week after starting PDT, gingival hyperplasia was partially reduced. Immediately after the end of treatment, a significant reduction of gingival hyperplasia was observed. PDT proved to be safe, quick and painless, with no esthetic harm. Conclusions: This case illustrates the benefit of a more conservative approach as opposed to surgical procedure, with good clinical response and decreased morbidity over a 2-year follow-up period.

show abstract

“…The reduction in cell proliferation can be related to the activation of the MAPK pathway, promoting an increased level of expression of the apoptosis related genes p38, JNK and ERK, PARP and caspase 3 [66]. Other studies have been conducted in order to identify new synthetic PS porphyrins to be applied on the treatment of this skin disorder [71,72].…”

Section: Psoriasismentioning

confidence: 99%

“…It has been shown that (Pc) 4 cause cell death when evaluated against cell lines derived from lymphoids (Jurkat) or epithelium (A431), highlighting singlet oxygen and ROS generation as possible inducers of cell death, acting in a dose-response way, i.e., the higher the concentration of the compound the greater the number of apoptotic cells [73]. The studies of phthalocyanines and porphyrins on PDT applied in the treatment of skin disorder are available in Table 3 [66,71,73,74,75].…”

Section: Psoriasismentioning

confidence: 99%

Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review

Annunzio

Costa

Mezzina

et al. 2019

IJMS

View full text Add to dashboard Cite

Recent scientific research has shown the use of chlorin, phthalocyanines, and porphyrins derivatives as photosensitizers in photodynamic therapy in the treatment of various pathologies, including some of the major skin diseases. Thus, the main goal of this critical review is to catalog the papers that used these photosensitizers in the treatment of acne vulgaris, psoriasis, papillomavirus infections, cutaneous leishmaniasis, and skin rejuvenation, and to explore the photodynamic therapy mechanisms against these conditions alongside their clinical benefits.

show abstract

Investigation of anti-inflammatory and anti-proliferative activities promoted by photoactivated cationic porphyrin

Cited by 14 publications

References 42 publications

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

A Conservative Approach for Localized Spongiotic Gingivitis Hyperplasia Using Photodynamic Therapy: A Case Report and Review of the Literature

Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review

Contact Info

Product

Resources

About