Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds

Augustine, Robin; Dominic, Edwin Anto; Reju, Indu; Kaimal, Balarama; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.1039/c4ra07361d

Cited by 173 publications

(126 citation statements)

References 53 publications

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“…Agglomerates of silver nanoparticles thus formed in the polymer matrix can act as stress concentration centers that prevent the stress transfer from the polymer matrix to the fillers. Whereas, at lower percentages of silver nanoparticle, there will be a uniform dispersion of silver nanoparticles in PCL polymer matrix, more uniform distribution of stress, minimized formation of stress concentration centers, increased interfacial area for stress transfer from the polymer matrix to the fillers, and good mechanical properties (Augustine et al 2014b). From the tensile testing results (Table 1), it is clear that the overall tensile properties were much higher for 0.5 wt% silver nanoparticle-incorporated membranes.…”

Section: Tensile Strengthmentioning

confidence: 81%

“…Further addition of silver nanoparticles resulted in a considerable reduction in fiber diameter, and at 1 wt% silver nanoparticle concentration, the average fiber diameter was 834 nm. Addition of silver nanoparticles resulted in the accumulation of a Appl Nanosci (2016) 6:337-344 339 higher charge density on the surface of the ejected jet during electrospinning, and the overall electric charges carried by the electrospinning jet significantly increased (Augustine et al 2014b). As the charges carried by the jet increased, higher elongation forces that could overcome the self-repulsion were brought down to the jet under the electrical field.…”

Section: Resultsmentioning

confidence: 98%

“…As the charges carried by the jet increased, higher elongation forces that could overcome the self-repulsion were brought down to the jet under the electrical field. Thus, as the charge density increased, the diameter of the fibers formed became substantially smaller and the diameter distribution of fibers became narrower (Augustine et al 2014b). …”

Section: Resultsmentioning

confidence: 99%

“…Apart from the bacterial barrier property, presence of antibacterial agents can successfully eliminate invasion and colonization of pathogens in the wound (Augustine et al 2014b). Wide range of biomaterials has been used by the medical practitioners to manage chronic wounds ).…”

Section: Introductionmentioning

confidence: 99%

“…The traditional wound dressings sustained for over 40-45 years, which were then replaced by the advanced materials which comprise of thin films that are permeable to vapor and gases. Examples of such film wound dressings include alginates, polyurethane films and hydrogels (Augustine et al 2013(Augustine et al , 2014b.…”

Section: Introductionmentioning

confidence: 99%

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Electrospun PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings

2015

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An open wound is highly prone to bacterial colonization and infection. Bacterial barrier property is an important factor that determines the success of a wound coverage material. Apart from the bacterial barrier property, presence of antibacterial agents can successfully eliminate the invasion and colonization of pathogen in the wound. Silver nanoparticles are well-known antimicrobial agents against a wide range of microorganisms. Biosynthesized silver nanoparticles are more acceptable for medical applications due to superior biocompatibility than chemically synthesized ones. Presence of biomolecules on biosynthesized silver nanoparticles enhances its therapeutic efficiency. Polycaprolactone (PCL) is a well-known material for biomedical applications including wound dressings. Electrospinning is an excellent technique for the fabrication of thin membranes for wound coverage applications with barrier property against microbes. In this paper, we report the fabrication and characterization of electrospun PCL membranes incorporated with biosynthesized silver nanoparticles for wound dressing applications.

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Section: Tensile Strengthmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrospun PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings

2015

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3D‐Printed Polyurethane Tissue‐Engineering Scaffold with Hierarchical Microcellular Foam Structure and Antibacterial Properties

et al. 2022

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This work proposes a facile fabrication strategy of polyurethane (TPU) tissue‐engineering scaffold with hierarchical structure, designed by combination of the fused deposition modeling (FDM) 3D printing and supercritical microcellular foaming by carbon dioxide (CO2). Further surface modification of TPU scaffold with graphene oxide (GO) was carried out by in situ polymerization of polydopamine (PDA) to ensure stable loading of GO with antibacterial properties. The influence of 3D‐printing temperature and speed on the microcellular cell morphology of TPU scaffold was investigated and optimized. The microcellular foaming and expansion process was indicated to compensate mechanical loss because of the gaps of stacking layers by FDM printing, and the reported tensile strength of 28 MPa matched well with that of natural cartilage tissue constructs. More interesting, the formation of interconnected open pores on the surface of foamed TPU scaffold shows much more enhanced cell adhesion because of the bigger specific surface area of microcellular structure. Similarly, the foamed TPU scaffold exhibits good absorption of GO nanosheets by the synthesized PDA on the surface and antibacterial properties, compared with the unfoamed TPU scaffold. This work offers a strategy for designing and manufacturing polymer tissue‐engineering scaffold with hierarchical structure and good antibacterial property.

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Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Wang

Cui

2020

Advanced Therapeutics

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Electrospinning is a versatile technique for generating ultrathin fibers, which is widely applied in various biomedical applications. The properties and structures of the fibers are specifically engineered to meet the needs of particular applications. The impact of nanofibrous scaffolds on biological processes is related to the promotion or inhibition of specific cell or bioactive substance functions. Here, a novel analysis of the diverse roles of electrospun nanofibrous scaffolds is provided and recent advances in exploiting their binary attributes for applications in biomedicine are summarized. This review initially introduces the development techniques for electrospinning, specifically the engineering of electrospun nanofibers. Then, scaffold applications for cell migration, adhesion, proliferation, and accelerating regeneration in cardiac, nerve, skeletal muscle, bone tissue, and wound healing are presented. Moreover, their inhibitory properties in cancer treatments, antibacterial applications, anti‐adhesion, anti‐scarring, and inhibition of thrombus formation are summarized. Eventually, the potential for future work using multifunctional, electrospun, nanofibrous scaffolds, in order to further inspire the development of scaffolds for biomedical treatments is summarized and discussed.

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Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds

Cited by 173 publications

References 53 publications

Electrospun PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings

Electrospun PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings

3D‐Printed Polyurethane Tissue‐Engineering Scaffold with Hierarchical Microcellular Foam Structure and Antibacterial Properties

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

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