Investigation of an outbreak of adenovirus type 3 infection in a boys' boarding school

Payne, Suzanne; Grilli, E. A.; Smith, Alyson; Hoskins, T. W.

doi:10.1017/s0022172400064809

Cited by 25 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common clinical diagnosis was exudative tonsillitis, which was different from that (pharyngoconjunctival fever) of the previous outbreaks in Australia in 2000, Japan in 1966, and USA in 1984 [8,11,15]. One hundred forty of 325 (43%) of our patients had lower respiratory tract infections (LRTI), including bronchitis, bronchiolitis, and pneumonia.…”

Section: Discussionmentioning

confidence: 69%

Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004–2005

et al. 2007

View full text Add to dashboard Cite

This study clinically and molecularly characterizes an adenovirus epidemic that broke out in Taiwan in April 2004. Clinical data on 325 children diagnosed with acute illness were collected between April 2004 and April 2005, and a diagnosis of adenovirus was confirmed by viral isolation. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the adenovirus genotypes in 267 patients. There was a seasonal variation, with a peak incidence between November 2004 and January 2005 (p < 0.001). The median age was 52 months, range 1-210 months. Most cases (90.8%) were younger than 7 years old. Male-to-female ratio was 1.56:1. The most common clinical diagnosis was exudative tonsillitis (50.8%), followed by bronchitis/bronchiolitis (29.9%), conjunctivitis or pharyngoconjunctival fever (22.5%), and acute otitis media (16.3%). Adenovirus type 3 was found in 215 patients (80.5%). The other 52 patients had other genotypes: type 2 (10.1%), type 1 (6.0%), type 5 (1.9%), type 7 (0.7%), type 4 (0.4%), and type 6 (0.4%). Patients with type 3 were significantly older [age >52 months, adjusted odds ratio (OR) 8.55, 95% confidence interval (CI) 1.84-40, p = 0.006), their family members had a higher incidence of illness (adjusted OR 8.77, 95% CI 1.55-50, p = 0.01), they coughed (adjusted OR 6.37, 95% CI 1.54-26.3, p = 0.01), and they had a higher C-reactive protein (CRP) level (>2.87 mg/dL, adjusted OR 3.64, 95% CI 1.06-12.3, p = 0.04) than the 52 cases with other genotypes. In conclusion, this adenovirus outbreak, from late autumn to winter, was predominately caused by adenovirus type 3. Patients with this genotype were significantly older, had a higher incidence of cough and family transmission, and had higher CRP levels than those with other genotypes.

show abstract

Section: Discussionmentioning

confidence: 69%

Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004–2005

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Symptoms, including fever (80% of cases), pharyngitis (69% of cases), and tonsillitis and cough (63% of cases), usually occur five to ten days after infection (Liu, 1991). Outbreaks in military recruits (Colon, 1991; Meiklejohn, 1983), hospitals (Colon, 1991; Brummett et al, 1988), and child‐care centers (Van et al, 1991; Bartlett et al, 1985; Payne et al, 1984) have been documented. In these outbreaks, acute respiratory disease and conjunctivitis were the most common illnesses.…”

mentioning

confidence: 99%

Sequential Disinfection of adenovirus type 2 with UV‐Chlorine‐Chloramine

Ballester¹,

Malley²

2004

Journal AWWA

View full text Add to dashboard Cite

Bench-scale experiments determined the inactivation rates of adenovirus serotype 2 with low-pressure, high-output ultraviolet (UV) light, chlorine (Cl 2 ), and preformed chloramines.Studies with sequential chloramines were also done to mimic water treatment practices. Sequential experiments with adenovirus serotype 2 suspended in laboratory-grade water and natural waters containing ammonia were exposed to either UV light followed by Cl 2 /chloramines or the reverse sequence. Adenovirus log reductions were quantified through cell culture techniques. A free Cl 2 C × T (concentration × time) of 1.22 mg-min/L resulted in a 3.72-log reduction, a preformed chloramine C × T of 264.5 mg-min/L resulted in a 1.2-log reduction, a sequential chloramine C × T of 40.5 mg-min/L resulted in a 1-log reduction, and a UV dose of 40 mJ/cm 2 resulted in a 1-log reduction. Up to 4-log reductions were achieved with a UV dose of 40 mJ/cm 2 followed by a sequential chloramine C × T of 27.2 mg-min/L. This suggests that sequential disinfection may be the best option for dealing with UV-resistant organisms such as adenoviruses.

show abstract

“…Pharyngoconjunctival fever is characterized by the triad of fever, pharyngitis, and acute follicular conjunctivitis, and causes epidemics in school‐aged children . This infection is caused by HAdV‐B and E, and presents as a flu‐like illness with conjunctivitis.…”

Section: Human Adenovirus‐disease Associationsmentioning

confidence: 99%

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

et al. 2019

View full text Add to dashboard Cite

Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.

show abstract

Investigation of an outbreak of adenovirus type 3 infection in a boys' boarding school

Cited by 25 publications

References 9 publications

Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004–2005

Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004–2005

Sequential Disinfection of adenovirus type 2 with UV‐Chlorine‐Chloramine

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

Contact Info

Product

Resources

About