Investigation of acute toxicity of cadmium chloride (CdCl2·H2O) metal salt and behavioral changes it causes on water frog (Rana ridibunda Pallas, 1771)

Selvı, Mahmut; Gül, Ali; Yılmaz, Mehmet

doi:10.1016/s0045-6535(03)00262-5

Cited by 24 publications

(6 citation statements)

References 12 publications

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“…Frogs in the control group were kept in clear water for following 10 days. The experimental groups were exposed to, respectively: nitrate lead (Pb(NO 3 ) 2 ) with a constant salt concentration of 28 mg/L (LC 50 for frogs of the P. ridibundus species was determined at the level of 138 mg/L [25]), mercuric chloride (HgCl 2 ) with a constant salt concentration of 1.353 mg/L (in the scientific literature, there is only one available piece of information concerning the value of LC 50 after exposition of X. leavis embryos to mercury chloride and it is equal to 0.163 mg/L [26]) and cadmium chloride, 2.5-hydrate (CdCl 2 2.5 H 2 O) with a constant salt concentration of 40 mg/L (LC 50 for frogs of the P. ridibundus species was determined at the level of 51.2 mg/L [27]). The used exposition concentrations are far above environmentally relevant concentrations.…”

Section: Animalsmentioning

confidence: 99%

Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress

2020

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The investigations showed changes of the cystathionine γ-lyase (CTH), 3-mercaptopyruvate sulfurtransferase (MPST) and rhodanese (TST) activity and gene expression in the brain, heart, liver, kidney, skeletal muscles and testes in frogs Pelophylax ridibundus, Xenopus laevis and Xenopus tropicalis in response to Pb 2+ , Hg 2+ and Cd 2+ stress. The results were analyzed jointly with changes in the expression of selected antioxidant enzymes (cytoplasmic and mitochondrial superoxide dismutase, glutathione peroxidase, catalase and thioredoxin reducatase) and with the level of malondialdehyde (a product of lipid peroxidation). The obtained results allowed for confirming the role of sulfurtransferases in the antioxidant protection of tissues exposed to heavy metal ions. Our results revealed different transcriptional responses of the investigated tissues to each of the examined heavy metals. The CTH, MPST and TST genes might be regarded as heavy metal stress-responsive. The CTH gene expression up-regulation was confirmed in the liver (Pb 2+ , Hg 2+ , Cd 2+ ) and skeletal muscle (Hg 2+ ), MPST in the brain (Pb 2+ , Hg 2+ ), kidney (Pb 2+ , Cd 2+ ), skeletal muscle (Pb 2+ , Hg 2+ ,Cd 2+ ) and TST in the brain (Pb 2+ ) and kidney (Pb 2+ , Hg 2+ , Cd 2+ ). Lead, mercury and cadmium toxicity was demonstrated to affect the glutathione (GSH) and cysteine levels, the concentration ratio of reduced to oxidized glutathione ([GSH]/[GSSG]) and the level of sulfane sulfur-containing compounds, which in case of enhanced reactive oxygen species generation can reveal their antioxidative properties. The present report is the first to widely describe the role of the sulfane sulfur/H 2 S generating enzymes and the cysteine/glutathione system in Pb 2+ , Hg 2+ and Cd 2+ stress in various frog tissues, and to explore the mechanisms mediating heavy metal-related stress.

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Section: Animalsmentioning

confidence: 99%

Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress

2020

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“…It has gained wide interest in the scientific community in recent years due to its potential human health hazards (Selvi et al, 2003). The main source of cadmium pollution is through soil.…”

Section: T Soad S Abdel Gawad 34mentioning

confidence: 99%

Toxicity and Bioaccumulation of Cadmium in the Freshwater Bivalve Corbicula Fluminalis Müller, 1774.

Gawad

2006

Egypt. J. of Aquatic Biolo. and Fish.

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“…Global amphibian population declines, range reduction and species extinctions have been reported with more regularity since the early 1980s and contribute to the world's current biodiversity crisis (Blaustein et al 1994a(Blaustein et al , 1994bSelvi et al, 2003;Whiles et al, 2006;Whitfield et al, 2007). Alarmingly, some species extinctions have even occurred in protected areas (Collins and Storfer, 2003).…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic effects of acidic pH on four subtropical frog species

Farquharson¹,

Wepener²,

Smit³

2016

WSA

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Acidic precipitation is implicated as a possible cause of global amphibian decline. Even protected areas such as Kruger National Park receive acid rain which may lead to possible negative effects on the park's natural amphibian populations. We conducted acute (LC 50 ) and chronic acid tolerance bioassays on embryos and tadpoles of four frog species found in the park, i.e., Chiromantis xerampelina (Southern Foam Nest Frog), Pyxicephalus edulis (African Bullfrog), Amietophrynus maculatus (Flat-backed Toad) and Hildebrandtia ornata (Ornate Frog), using survival, deformities and growth as endpoints. Chronic exposure pH-values were selected based on the results of the acute assays. Trimmed Spearman-Karber LC 50 s were 4.07, 4.55, 3.75 and 3.747 for C. xerampelina, P. edulis, A. maculatus and H. ornata, respectively, and were all below the pHs in the natural ponds of the KNP. For chronic exposures tadpole size decreased and tadpole deformities increased with decreasing pH. Metamorphosis of tadpoles was also delayed by increasing acidity. In conclusion, the current buffering capacity of water bodies, which serve as habitat for amphibians, negates the effects of decreasing pH from acid precipitation.

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Investigation of acute toxicity of cadmium chloride (CdCl2·H2O) metal salt and behavioral changes it causes on water frog (Rana ridibunda Pallas, 1771)

Cited by 24 publications

References 12 publications

Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress

Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress

Toxicity and Bioaccumulation of Cadmium in the Freshwater Bivalve Corbicula Fluminalis Müller, 1774.

Acute and chronic effects of acidic pH on four subtropical frog species

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