Investigation of Activities Related to Wound Healing of Secamone Afzelii

Mensah, Abraham Yeboah; Houghton, PJ; Agyare, Christian; Komlaga, Gustav; Mensah, Merlin Lincoln Kwao; Fleisher, T C; Sarpong, Kwame

doi:10.4314/just.v26i3.33008

Cited by 7 publications

(9 citation statements)

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“…The total phenol content, total antioxidant capacity as well as and free radical scavenging ability were also investigated. Phytochemical screening of the powdered bark of S. afzelii, revealed the presence of bioactive components specifically flavonoids, triterpenes and coumarins which confirms previous works done (Mensah et al, 2004, Mensah et al, 2007, Zabri et al, 2008.…”

Section: Resultssupporting

confidence: 76%

“…Previous studies have shown that Secamone afzelli has in vitro antimicrobial activity and the plant extract is able to protect cells against damage by free oxygen radicals (Houghton et al, 2005, Mensah et al, 2007. The total extract also showed effective free radical scavenging activity in non-enzymatic lipid peroxidation in liposomes which was attributed to α-tocopherol extracted from the leaf (Mensah et al, 2004).…”

Section: Introductionmentioning

confidence: 78%

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Anti-inflammatory and anti-oxidant activities of <i>Secamone afzelii</i> (Rhoem) Ascleipiadaceae

Mensah¹,

Mireku²,

Okwuonu³

2014

J. Med. Biomed. Sci.

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Secamone afzelii is used traditionally in Ghana mainly as a wound healing agent. This study reports the anti-inflammatory and antioxidant properties of S. afzelii. The anti-inflammatory activity was determined by the carrageenan-induced paw oedema method in 7 day old chicks and antioxidant property by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, total antioxidant and total phenol content determinations. In doses of 30, 100 and 300 mg kg -1 , the methanol extract of the leaves reduced carrageenan-induced oedema by 24.70%, 33.41% and 44.26% respectively. The leaf extract exhibited free radical scavenging activity with an IC50 of 16.73 µg mL -1 compared to ascorbic acid which gave an IC50 of 2.01 µg mL -1 . In the total phenol content determination, the leaf extract was found to contain 56.86 mg g -1 calculated as tannic acid equivalent of the dry weight of extract. The extract also demonstrated remarkable antioxidant effect in the total antioxidant capacity determinations and had an 87% correlation with the amount of phenolic content present.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 78%

Anti-inflammatory and anti-oxidant activities of <i>Secamone afzelii</i> (Rhoem) Ascleipiadaceae

Mensah¹,

Mireku²,

Okwuonu³

2014

J. Med. Biomed. Sci.

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“…In this study, MoWE was examined for its potential as an anticancer drug candidate on MCF-7. Preliminary studies on some of the medicinal plants have indicated their cytotoxicity towards pathogenic bacteria and cancer cell lines (Mensah et al, 2006 andBayor et al, 2007).They examined some traditional medicinal plants and identified their cytotoxicity towards MCF-7 cells and other cancer cell lines.…”

Section: Figure -8: Nutritive Values Of Different Biscuit Samples With Dmol Discussionmentioning

confidence: 99%

دراسة التأثيرات المضادة للسرطان للمستخلص المائى لأوراق نبات المورينجا أوليفيرا على خلايا سرطان الثدي McF-7 مع إمکانات استخدام مسحوق أوراقها کإضافة في بعض المنتجات الغذائية

الاصفهانى¹,

النبى²,

الجروانى³

et al. 2020

مجلة الاقتصاد المنزلي.جامعة المنوفية

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Breast cancer is the most common cancer among women, representing 23% of the total new cases and the second leading cause of cancer death in women. Natural medicines have been proven to be a good source of narrative agents with a pharmaceutical potential. Moringa oleifera consists of diverse plant chemicals that exhibit anti-cancer action through cytotoxic effects on various cancer cells. The objectives of the present study are to explore the effects of natural compounds of Moringa oleifera leaf water extract (MoWE) on the proliferation of MCF-7 cells. The second objective is to investigate the possibility of using Moringa oleifera (whole leaf) as natural food additives in some food products (gruel and biscuits). Results showed that MoWE possesses antioxidant scavenging DPPH activity (74.53%). Total polyphenolics, flavonoids and tannins were 44.77 mg GAE/ml, 5.86 and 22.16 mg QE /ml, respectively. The MoWE also exerted cytotoxic effect on MCF-7 cells with IC50 = 600µg/ml. MoWE induced down regulation of Bcl-2 and up-regulation of Bax proteins expression levels. The elevation of fourteen folds in Bax/Bcl-2 ratio was recorded in MoWE-treated groups. These results suggest that Moringa leaf water extract may have beneficial effects for the reduction of breast cancer growth, and new therapeutic strategy for the treatment of human cancers. The nutritive values of both gruel and biscuit were improved. The proximate chemical composition of gruel in the sample-3 (7.5%) was contained 21.86% moisture, 8.85 % protein, 5.28 % fat, 68.48% carbohydrate, 2.28% ash. While the proximate chemical composition of gruel in the sample-3 (7.5%) was contained 7.6% moisture, 10.21 % protein, 6.21 % fat, 73.56% carbohydrate, 1.8% ash. So Moringa oleifera leaf powder can be used as food additives to elevate the nutritive value of children foods.

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“…A decoction of the whole plant is used as a galactagogue [26]. Studies have shown that S. afzelli has antimicrobial effects and also protect cells against damage by reactive oxygen species [27][28][29][30]. The anti-inflammatory property of the leaf extract has also been demonstrated [30]…”

Section: Asclepiadaceaementioning

confidence: 99%

Medicinal Plants Used as Galactagogues

Bekoe¹,

Kitcher²,

Gyima³

et al. 2019

Pharmacognosy - Medicinal Plants

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The recommended diet for human infants within the first 6 months of life is breast milk. No other natural or artificial formulation has been able to match up to this gold standard. Mothers who have attempted to pursue exclusive breastfeeding can, however, attest to numerous nutritional and non-nutritional challenges mainly resulting in insufficient milk production (hypogalactia) or the absence of milk production (agalactia). There are very few and officially recommended orthodox drugs to increase lactation. The most widely used galactagogues being chlorpromazine, sulpiride, metoclopramide and domperidone are associated with very high incidences of unpleasant side effects including their extra-pyramidal effects in both mother and infant. There is therefore a need to keep searching for more acceptable galactagogues. This section reviews current literature on medicinal plants used within the local Ghanaian community to enhance lactation. Various electronic databases such as PubMed, Science Direct, SciFinder and Google Scholar as well as published books on Ghanaian medicinal plants were searched. A total of 22 plants belonging to 13 families were reviewed with regards to their medicinal values, information on lactation and toxicity.

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Investigation of Activities Related to Wound Healing of Secamone Afzelii

Cited by 7 publications

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Anti-inflammatory and anti-oxidant activities of <i>Secamone afzelii</i> (Rhoem) Ascleipiadaceae

Anti-inflammatory and anti-oxidant activities of <i>Secamone afzelii</i> (Rhoem) Ascleipiadaceae

Medicinal Plants Used as Galactagogues

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