Investigation of ABCB1 gene polymorphism with colchicine response in Behçet’s disease

Sarıcaoğlu, Hayriye; Yilmaz, Meryem; Karkucak, Mutlu; Ozturk, Hamdi; Yakut, Tahsin; Gulten, T; Başkan, Emel Bülbül; Aydoğan, Kenan; Dilek, Kamıl

doi:10.4238/vol10-1gmr824

Cited by 14 publications

(10 citation statements)

References 11 publications

(11 reference statements)

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“…Results of this study show that C3435T polymorphism is not associated with the Behcet's disease and the drug response (Saricaoglu et al, 2011).…”

Section: Discussionmentioning

confidence: 62%

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Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever

Rüstemoğlu¹,

Gümüş-Akay²,

Yığıt³

et al. 2011

Genet. Mol. Res.

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“…Results of this study show that C3435T polymorphism is not associated with the Behcet's disease and the drug response (Saricaoglu et al, 2011).…”

Section: Discussionmentioning

confidence: 62%

“…In a recent study by Saricaoglu et al (2011), the effect of MDR1 C3435T polymorphism was analyzed in Behçet's disease. Results of this study show that C3435T polymorphism is not associated with the Behcet's disease and the drug response (Saricaoglu et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever

Rüstemoğlu¹,

Gümüş-Akay²,

Yığıt³

et al. 2011

Genet. Mol. Res.

View full text Add to dashboard Cite

“…Although any difference between the BD patients and control subjects was not observed in the distribution of alleles, the CC genotype was found to be comparatively increased in BD cases (Saricaoglu et al, 2011).…”

Section: Introductionmentioning

confidence: 94%

“…The only study in the literature that recently investigated the relationship between BD and MDR1 gene polymorphisms was performed by Saricaoglu et al, 2011. In this study, MDR1 C3435T polymorphism was investigated in patients with BD. Although any difference between the BD patients and control subjects was not observed in the distribution of alleles, the CC genotype was found to be comparatively increased in BD cases (Saricaoglu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

MDR1 gene polymorphisms may be associated with Behçet's disease and its colchicum treatment response

Rüstemoğlu

Gül

Gümüş-Akay

et al. 2012

Gene

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“…35 No relationship was detected between MDR1 C3435T polymorphism and colchicine response in patients with Behçet's disease. 36 In addition, our colchicineunresponsive patient population is more than twice the other studies and it makes our results more reliable. In a study, another mutation of MDR1 (G185V) was found to increase colchicine resistance.…”

Section: Discussionmentioning

confidence: 47%

Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients

et al. 2011

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The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and drugs. The TT genotype of 3435 codon in exon 26 of MDR1 gene causes overexpression of gene activity and effluxes many chemically diverse compounds across the plasma membrane. We studied the association between C3435T polymorphisms (single nucleotide polymorphism) of MDR1 gene and colchicine-resistant familial Mediterranean fever (FMF) patients. Total genomic DNA samples from 52 FMF patients of colchicine unresponsiveness were used for FMF (MEFV) and MDR1 genes profile analyses. Target genes were genotyped by multiplex PCR-based reverse-hybridization Strip Assay method. The preliminary current results showed increased T allele frequency (0.596) in colchicine unresponsiveness of FMF patients. The distributions of the CC, CT, and TT genotypes in colchicine nonresponder FMF patients were 17%, 46%, and 37%, respectively. Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine resistance in nonresponder FMF patients during the common therapy protocol.

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Investigation of ABCB1 gene polymorphism with colchicine response in Behçet’s disease

Cited by 14 publications

References 11 publications

Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever

Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever

MDR1 gene polymorphisms may be associated with Behçet's disease and its colchicum treatment response

Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients

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