Investigation of a Series of Silver–N‐Heterocyclic Carbenes as Antibacterial Agents: Activity, Synergistic Effects, and Cytotoxicity

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

“…Presumably the less polar solvent causes the precipitation of silver bromide, hence the salt does not become incorporated into the structure. The resonance in the 1 H NMR spectra attributable to the C2 proton disappears upon deprotonation and resulting carbene formation, and a shift at approximately 180 ppm in the 13 C NMR spectra shows the C2 carbon coordinating to silver.…”

Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes – Synthesis and biological evaluation

“…Furthermore led the synthesis and antimicrobial evaluation of NHC silver complexes derived from 1-benzyl-3-tert-butylimidazole by Ghosh et al to another important contribution [8]. Additionally a larger number of known compounds were evaluated as potential antibiotics by Roland and Jolivalt [9]. Recently, Gust et al reported the anticancer activity of 4,5-diaryl-imidazole derived NHC silver complexes against MCF-7, MDA-MB-231 (breast) and HT-29 (colon) cancer cell lines [10].…”

N -Heterocyclic Carbene Metal Complexes as Bio-Organometallic Antimicrobial and Anticancer Drugs

“…Some complexes were efficient at low concentrations against resistant strains of Staphylococcus aureus that caused major problems to public health. Excitingly, NHC-silver complex 38 revealed lowest cytotoxicity on the epithelioma papulo- The influence of the NHC structure on antimicrobial activity and cytotoxicity was further investigated to explore their potential as antimicrobial and anticancer agents [106].…”