1977
DOI: 10.1016/0002-9343(77)90152-8
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Investigation of a new parameter in chronic lymphocytic leukemia: The percentage of large peripheral lymphocytes determined by the Hemalog D

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Cited by 49 publications
(15 citation statements)
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“…There was some variation in the pattern of the LUC population as seen on the oscilloscope display, indicating varia tion in cell size. Binet et al [4] compared the ratio of LUC to the total number of lymphocytes in CLL and control subjects, and found that the CLL patients with values higher than the control range were those with advanced disease in their clinical stag ing system. Our small number of patients in this group has not allowed us to confirm or refute these findings.…”
Section: Discussionmentioning
confidence: 99%
“…There was some variation in the pattern of the LUC population as seen on the oscilloscope display, indicating varia tion in cell size. Binet et al [4] compared the ratio of LUC to the total number of lymphocytes in CLL and control subjects, and found that the CLL patients with values higher than the control range were those with advanced disease in their clinical stag ing system. Our small number of patients in this group has not allowed us to confirm or refute these findings.…”
Section: Discussionmentioning
confidence: 99%
“…Although CLL remains an incurable disorder, early stage detection and treatment can control disease progression, whereas late stage patients are often unresponsive to various treatments (4). Even though CLL often presents with a heterogeneous pathology in the clinic, most patients receive a few standardized treatments, primarily on the basis of limited clinical parameters such as Rai or Binet staging, which classify CLL patients on the basis of the spreading of the disease and its cytogenetic characterization, underlining the need for more informative diagnostic markers with better clinical significance (5,6).…”
mentioning
confidence: 99%
“…To this end, it has been suggested that differ ences in cell size [2,[4][5][6][7][8] and enzyme activities [9][10][11][12] of the circulating B-CLL lymphocytes may relate to the different clinical behaviour of the disease. In a previous report [13], an attempt was made to evaluate the activity of lymphocyte adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and lactate dehydrogenase (LDH) in two morphological subgroups of B-CLL classified according to the per centage of circulating large non-granular atypical lymphocytes (AL).…”
Section: Introductionmentioning
confidence: 99%