Investigation of a breast cancer magnetic hyperthermia through mathematical modeling of intratumoral nanoparticle distribution and temperature elevations

Mahesh, Nandyala; Singh, Neetu; Talukdar, Prabal

doi:10.1016/j.tsep.2023.101756

Cited by 3 publications

(2 citation statements)

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“…Its pathophysiology presents a series of challenges, including the need to identify new prevention and treatment strategies, aiming to improve patients’ quality of life affected by this disease [ 46 , 47 , 48 , 49 ]. Recent studies have provided promising evidence of the benefits of omega-3 supplementation and complementary therapies in combination with chemotherapy, radiotherapy, and surgical procedures for patients with BC [ 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training

Theinel,

Nucci,

Cianciarullo

et al. 2024

Pharmaceutics

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Breast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed to evaluate the efficacy of magneto-hyperthermia (MHT) therapy associated with supplementation with omega-3 polyunsaturated fatty acid (w-3 PUFA) and engagement in physical training (PT) for the triple-negative BC (TNBC) model. First, we assessed the physicochemical properties of iron oxide nanoparticles (ION) in biological conditions, as well as their heating potential for MHT therapy. Then, a bioluminescence (BLI) evaluation of the best tumor growth conditions in the TNBC model (the quantity of implanted cells and time), as well as the efficacy of MHT therapy (5 consecutive days) associated with the previous administration of 8 weeks of w-3 PUFA and PT, was carried out. The results showed the good stability and potential of ION for MHT using 300 Gauss and 420 kHz. In the TNBC model, adequate tumor growth was observed after 14 days of 2 × 106 cells implantation by BLI. There was a delay in tumor growth in animals that received w-3 and PT and a significant decrease associated with MHT. This pioneering combination therapy approach (MHT, omega-3, and exercise) showed a positive effect on TNBC tumor reduction and demonstrated promise for pre-clinical and clinical studies in the future.

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Section: Discussionmentioning

confidence: 99%

Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training

Theinel,

Nucci,

Cianciarullo

et al. 2024

Pharmaceutics

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show abstract

“…14 This method aims to target cancer cells by elevating the temperature above the physiological level, triggering cell death or damage. 15,16 One of the mechanisms of cell death due to heat is believed to be protein denaturation. Individual proteins have a temperature limit to which they can be exposed, and denaturation occurs at temperatures above 40 °C.…”

Section: Introductionmentioning

confidence: 99%