Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent

Peloso, Eduardo de Figueiredo; Merli, Rafaella Junqueira; Espuri, Patrícia Ferreira; Nunes, Juliana Barbosa; Colombo, Fábio Antônio; Sierra, Elkin Jose Torres; Paulo, Daniela Carvalho de; Santos, Marcelo Henrique dos; Carvalho, Diogo Teixeira; Marques, Marcos José

doi:10.1007/s11033-020-05887-5

Cited by 9 publications

(1 citation statement)

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“…Scopoletin (6-methoxy-7-hydroxy-coumarin) increased the phagocytic ability of macrophages in a human based monocytic cell line [43]. Several 7-methoxy-8-[3-methylpent-2-enyl] coumarin (osthole) derivatives showed meaningful anti-tumor activity in cell culture models [42][43][44][45][46][47][48]. Moreover, the 4-hydroxycoumarin impairs the ability of melanoma cells to metastasize [49] and although this effect is probably not immune related, it may contribute to presenting tumorous antigens to the immune system.…”

Section: Coumarins With Potential Immunity Enhancing Effectsmentioning

confidence: 99%

Coumarins and their Derivatives as Potential Modulators of Immune Response

Bipat

2024

Adv Res Sci

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Coumarins are molecules varying from simple to more complex compounds that are widely available in nature, while some of them have been synthesized. They possess significant pharmacological potential, but until now their applicability in medicine has been limited to their ability to limit coagulation in blood. Our immune system plays a major role in disease states, with both ends of the spectrum being significant. Both a slow or absent immune reaction on one hand and an overreaction of the system on the other hand may be detrimental to our health. Since the process of coagulation seems to be related to the immune system, studies showing a possible role for coumarins and their lead compounds in modulating the immune system. were searched for in databases like PubMed, Google Scholar and Hinari. Several studies with promising results revealing a role for coumarins in modulating the immune response, were found However, all these studies have been carried out in in vitro and simple animal models. Randomized clinical trials will be required to demonstrate the therapeutic value of these readily available coumarin compounds.

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