Investigation into the intake of a popular polyherbal drug (Jalin Herbal Mannex Liquid) on selected biochemical indices of male wister rats

Abstract

Jalin Herbal Mannex Liquid (JHML) is a polyherbal formulation from honey, Panax ginseng, Liriosma ovate, and Lepidium mehenil, intended for enhanced sexual performance and improve sperm count in men. JHML was studied via its effect on body weight, biochemical indices and histopathology of the testes. Twenty healthy Wistar rats of 120 -150 g weight were allotted into groups A and B., of ten rats each, group A (control), were given 2 mL/kg B.W of tap water, group B were dosed with 2 mL/kg B.W of JHML for four weeks with the animals allowed access to feed and water ad-libitum. Blood were obtained through heart perforation, kidney and testes were excised, washed with normal buffered saline. Results from the investigation indicated that JHML had androgenic properties with marked significant increase (p˂0.05) in body weight of rats administered with JHML. Significant increase (p˂0.05) was observed in LH, FSH, testosterone and with a concomitant significant decrease (p˂0.05) in PRL. The JHML caused non-significant decrease (p>0.05) on triglycerides and cholesterol but with positive significant effect (p˂0.05) on LDL and HDL. No significant changes (p>0.05) on creatinine, urea, uric acid and serum electrolytes. Testicular sections of rats treated with JHML exhibited normal features, seminiferous epithelium and interstitial tissues with active spermatogenesis. The significant increase (p˂0.05) in testosterone, LH, FSH with a concomitant significant decrease (p˂0.05) in PRL may account for its sex invigorating potential, the non-significant changes observed in some biochemical indices of the rats showed that JHML is relatively safe at the studied dose.