Although nowadays finite difference simulators have many advantages for reservoir engineers to predict reservoirs in 3 dimensions, they have some disadvantages; such as spending much run time for complex fields with several thousand grids which by using Streamline simulation, the run time was decreased a lot. In this paper, first a brief summary of streamline simulation and its uniqueness applications were discussed and then an Iranian oil reservoir as a case study was simulated by using FrontSim streamline simulator, then besides testing the results of Sayyafzadeh et al (2010) to find the location of infill wells, the most suitable locations for infill drilling were selected, after that, vertical and horizontal infill wells were investigated and overally 34 scenarios were tested by using Streamline simulation method and FrontSim software, finally the results of simulation and testing infill drilling scenario shows significant increasing in field oil production and field oil recovery factor, approximately 13%, and also reduction field water cut. In addition, distinguishing fractures or faults, well's drainage area and understanding that how much injectors affect the field oil production are other benefits of Streamline simulation method. The Novelty of this paper was to study the effects of horizontal infill wells and comparing the results between horizontal and vertival infill drilling using streamline simulation.