Investigation into liquisolid system processability based on the SeDeM Expert System approach

Vasiljević, Ivana; Turković, Erna; Nenadović, Snežana; Mirković, Miljana; Zimmer, Andreas; Parojčić, Jelena; Aleksić, Ivana

doi:10.1016/j.ijpharm.2021.120847

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…Additionally, mathematical transformation was added to the MCS to improve sample characterization and comparison. The results obtained provided insight into multiparticulate material properties and contributed to a mechanistic understanding of the factors governing their processability, and they may serve as a useful tool in multiparticulate dosage forms development (47)(48)(49)(50). Mathematical approaches exhibited sufficient discriminatory power to depict the differences among multiparticulate units prepared by different methods, since preparation technology represents the main factor affecting MPU characteristics.…”

Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 98%

“…Due to different multiparticulate unit manufacturing methods and composition, the evaluation of their processability is both highly needed and challenging. In order to improve multiparticulate units characterization and provide an in-depth understanding of multiparticulate unit properties, mathematical approaches have been applied (42)(43)(44)(45)(46)(47)(48)(49)(50).…”

Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 99%

“…Our research group performed a different multiparticulate units characterization (pellets obtained by extrusion/spheronization, granules obtained by wet granulation, liquisolid pellets, liquisolid powders, 3D printed MPUs) based on the CBCS, MCS and SeDeM Expert System (47)(48)(49)(50). Although initially developed for powder characterization, these mathematical approaches provided valuable insight into the attributes of multiparticulate samples affecting their processability.…”

Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 99%

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Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Vasiljević¹,

Turković²,

Aleksić³

et al. 2022

Arhiv za farmaciju

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An understanding of material properties and processing effects on solid dosage forms performance is required within the Quality-by-design approach to pharmaceutical development. Several research groups have developed mathematical approaches aiming to facilitate the selection of formulation composition and the manufacturing technology. These approaches are based on material particulate, bulk and compression-related properties. This paper provides theoretical assumptions and a critical review of different mathematical approaches for processability characterization of powders and multiparticulate units. Mathematical approaches have mainly been developed for directly compressible materials, but sometimes other manufacturing technologies, such as roller compaction and wet granulation, are also considered. The obtained compact tensile strength has been implemented in the majority of approaches, as an important characteristic describing compact mechanical properties. Flowability should be also evaluated, since it affects sample processability. Additionally, particle size and shape, material density and compressibility, compactibility and tabletability profiles have been also distinguished as relevant properties for solid dosage form development. The application of mathematical approaches may contribute to the mechanistic understanding of critical material attributes and facilitate dosage form development and optimization. However, it is essential to select the appropriate one, based on the intended dosage form characteristics, in order to ensure that all relevant powder/multiparticulate units characteristics are implemented and critically evaluated.

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Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 98%

Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 99%

Section: Applicability Of Expert Systems In Multiparticulate Units Ch...mentioning

confidence: 99%

See 1 more Smart Citation

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Vasiljević¹,

Turković²,

Aleksić³

et al. 2022

Arhiv za farmaciju

Self Cite

View full text Add to dashboard Cite

show abstract

“…The preparation of an LS system involves a simple mixing procedure, schematically represented in Figure 1. Spireas (7) described in detail the preparation procedure in a mortar with the aid of a pestle, and in a few studies it has been shown that the equipment commonly used for solid dosage forms production, such as a fluid bed processor (9,10) or an extruder/spheronizer, could be used for the production of LS systems (11,12). The excipients required for the preparation of an LS system involve: a carrier, coating material and liquid vehicle (if liquid medication represents the dispersion of an API in a suitable liquid).…”

Section: Components Of Liquisolid Formulationsmentioning

confidence: 99%

“…The most frequently used coating material is colloidal silica (Aerosil ® 200). Other excipients used as coating materials include: Neusilin ® UFL2 (17), Florite ® (calcium silicate) (18), Syloid ® 244 FP (mesoporous amorphous silica) (19) and crospovidone (11,12).…”

Section: šEmatski Prikaz Pripreme Tečno-čvrstih Sistemamentioning

confidence: 99%

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Aleksić¹,

Glišić²,

Parojčić³

2022

Arhiv za farmaciju

Self Cite

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Liquisolid systems are a novel, promising platform for the production of solid dosage forms with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid vehicle or liquid drug. This technology requires conventional, but highly porous excipients (carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication, resulting in both good flowability and acceptable compression properties. This approach has shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs, and has been recognized as a good alternative to common, more complex and expensive techniques. A variety of applications of this simple technique have been investigated recently, including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and the most important are: simplicity, cost-effectiveness, applicability in large scale production and environmental friendliness. However, it is accompanied by certain challenges as well, such as limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive overview of recent progress regarding the potential applications of this technology, as well as to give an insight into the new liquisolid-based techniques intending to further support its commercial applicability.

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A Review on Research and Application of Expert Systems on Drug Formulation and Process Design

Du,

Zhang

2024

Exploring Computational Pharmaceutics ‐ AI and Modeling in Pharma 4.0

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Investigation into liquisolid system processability based on the SeDeM Expert System approach

Cited by 10 publications

References 28 publications

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

A Review on Research and Application of Expert Systems on Drug Formulation and Process Design

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