Investigation for the Characteristic Anticoccidial Activity of Diclazuril in Battery Trials.

Matsuno, Toshimi; Kobayashi, Nobuo; Hariguchi, Fumio; Okamoto, Takuji; Okada, Yukitaka; Hayashi, Tetsu

doi:10.1292/jvms.58.129

Cited by 2 publications

(1 citation statement)

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“…Furthermore, the allicin content of garlic can inhibit the parasitic RNA synthesis and activate the natural killer immune cells ( 46 ). The anticoccidial effect of diclazuril is noted in its ability to disturb the different stages of the Eimeria species life cycles by inhibiting the amylopectin synthesis, which is a main component of the cell wall of E. tenella parasitic stage ( 47 ). Furthermore, diclazuril downregulates the microneme genes, leading to reduction in the second-generation merozoites of E. tenella ( 48 ), and the enzyme expressions that are responsible for the E. tenella cell replication ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

S-Methylcysteine Ameliorates the Intestinal Damage Induced by Eimeria tenella Infection via Targeting Oxidative Stress and Inflammatory Modulators

et al. 2022

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Avian coccidiosis is one of the major parasitic diseases in the poultry industry. The infection is caused by Eimeria species, and its treatment relies mainly on the administration of anticoccidial drugs, which can result in drug resistance and side effects. The recent trends in avian coccidiosis treatment is directed to the development of a new therapy using herbal compounds. S-Methylcysteine (SMC) is considered one of the organosulfur compounds in garlic that showed promising activity in the treatment of different pathological conditions via a wide range of anti-inflammatory and antioxidant mechanisms. In this study, the anticoccidial activity of SMC was investigated in Eimeria tenella-infected chickens compared to diclazuril as a widely used anticoccidial drug. In this regard, 14-day-old broilers were divided into six groups (n = 18). The first group (G1) was the healthy control group, while the second group (G2) was the non-infected SMC group treated at a dose of 50 mg/kg b.w. (high dose). Moreover, the third group (G3) was the positive control group (infected and non-treated). The fourth group (G4) was the infected group treated with SMC of 25 mg/kg b.w. (low dose), while the fifth group (G5) was the infected group treated with SMC of 50 mg/kg b.w. (high dose). Conversely, the sixth group (G6) was the diclazuril-treated group. The anticoccidial effects of SMC and diclazuril were evaluated by counting oocysts and recording the body weight gain, feed conversion ratio, clinical signs, lesions, and mortality rate. Interestingly, SMC showed potent anticoccidial activity, which was exemplified by reduction of oocyst count. Furthermore, the biochemical, antioxidant, and anti-inflammatory parameters in the cecal tissues were restored toward their control levels in G4, G5, and G6. Histopathological observation of cecal tissues was consistent with the aforementioned results revealing the ameliorative effect of SMC against E. tenella infection. This study concluded novel findings in relation to the anticoccidial role of SMC as a plant-based compound against the E. tenella-induced coccidiosis in broiler chickens combined with its antioxidative and anti-inflammatory properties. Further studies for exploring the mechanistic pathways involved in this activity and the potential benefits from its use in association with conventional anticoccidial drugs are warranted.

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