Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology

Chen, Yang; Li, Qian; Ren, Sisi; Chen, Ting; Zhai, Bingtao; Cheng, Jiangxue; Shi, Xun; Song, Liang; Fan, Yu Shan; Guo, Dongyan

doi:10.1631/jzus.b2200038

Cited by 6 publications

(3 citation statements)

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“…It is demonstrated that curcumin (CUR) induces pyroptosis in HspG2 cells by increasing ROS [ 168 ]. In addition, CUR may inhibit the growth of HepG2 cells by promoting the P53-dependent apoptosis [ 169 ]. Moreover, CUR triggers mitochondrial apoptosis in HCC cells by inhibiting the PI3K/Akt/glycogen synthase kinase-3 β (GSK-3 β ) signaling pathway [ 170 , 171 ].…”

Section: Pyroptosis and Cancermentioning

confidence: 99%

“…signaling pathway [169][170][171] 17β-estradiol Induces the activation of NLRP3 infammasome [173] Increases FOXO3 phosphorylation, induces oxidative stress, and downregulates IL-6/STAT3 signaling [174,175] Berberine Induces caspase-1-dependent pyroptosis [176] Regulates NF-κB/p65 pathway and induces adenosine AMPK-mediatedcaspase-dependent apoptosis [177,178] Euxanthone Promotes pyroptosis in a caspase-dependent manner [156] Alpinumisofavone Induces NLRP3 infammasome-mediated pyroptosis [157] Breast cancer Polydatin Downregulates the JAK2 and STAT3 levels [184] Suppresses the ROS/PI3K/Akt pathway [185] Cisplatin Activates the NLRP3/caspase-1/GSDMD pathway [186] Downregulates the PI3K/Akt/mTOR signaling pathway [187] Table 1: Continued.…”

Section: Hepatic Carcinoma Crizotinibmentioning

confidence: 99%

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Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Qian

Bai

et al. 2022

Journal of Oncology

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As a type of regulated cell death (RCD) mode, pyroptosis plays an important role in several kinds of cancers. Pyroptosis is induced by different stimuli, whose pathways are divided into the canonical pathway and the noncanonical pathway depending on the formation of the inflammasomes. The canonical pathway is triggered by the assembly of inflammasomes, and the activation of caspase-1 and then the cleavage of effector protein gasdermin D (GSDMD) are promoted. While in the noncanonical pathway, the caspase-4/5/11 (caspase 4/5 in humans and caspase 11 in mice) directly cleave GSDMD without the assembly of inflammasomes. Pyroptosis is involved in various cancers, such as lung cancer, gastric cancer, hepatic carcinoma, breast cancer, and colorectal carcinoma. Pyroptosis in gastric cancer, hepatic carcinoma, breast cancer, and colorectal carcinoma is related to the canonical pathway, while both the canonical and noncanonical pathway participate in lung cancer. Moreover, simvastatin, metformin, and curcumin have effect on these cancers and simultaneously promote the pyroptosis of cancer cells. Accordingly, pyroptosis may be an important therapeutic target for cancer.

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Section: Pyroptosis and Cancermentioning

confidence: 99%

Section: Hepatic Carcinoma Crizotinibmentioning

confidence: 99%

Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Qian

Bai

et al. 2022

Journal of Oncology

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“…Multiple findings have recently indicated the anticancer potential of CUR for the therapy of HCC [ 131 , 132 ]. In particular, several nanotechnological solutions have been investigated to overcome its scarce water solubility and bioavailability.…”

Section: Newly Developed Ha-based Nanocarrier Systems Loading Phecs A...mentioning

confidence: 99%

Hyaluronic Acid-Mediated Phenolic Compound Nanodelivery for Cancer Therapy

et al. 2023

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Phenolic compounds are bioactive phytochemicals showing a wide range of pharmacological activities, including anti-inflammatory, antioxidant, immunomodulatory, and anticancer effects. Moreover, they are associated with fewer side effects compared to most currently used antitumor drugs. Combinations of phenolic compounds with commonly used drugs have been largely studied as an approach aimed at enhancing the efficacy of anticancer drugs and reducing their deleterious systemic effects. In addition, some of these compounds are reported to reduce tumor cell drug resistance by modulating different signaling pathways. However, often, their application is limited due to their chemical instability, low water solubility, or scarce bioavailability. Nanoformulations, including polyphenols in combination or not with anticancer drugs, represent a suitable strategy to enhance their stability and bioavailability and, thus, improve their therapeutic activity. In recent years, the development of hyaluronic acid-based systems for specific drug delivery to cancer cells has represented a pursued therapeutic strategy. This is related to the fact that this natural polysaccharide binds to the CD44 receptor that is overexpressed in most solid cancers, thus allowing its efficient internalization in tumor cells. Moreover, it is characterized by high biodegradability, biocompatibility, and low toxicity. Here, we will focus on and critically analyze the results obtained in recent studies regarding the use of hyaluronic acid for the targeted delivery of bioactive phenolic compounds to cancer cells of different origins, alone or in combination with drugs.

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