Abstract:compared with that of free protoheme-N-base complexes [5]. It is well known that binding of heterotropic effectors reduces the O 2 -affinity of Hb (increases in P 50 ), whereas binding of O 2 does not change the P 50 value of Hb. Effectorlinked enhancements of high-frequency thermal fluctuations of globin [6] increase the transparency of globin matrix toward migrating diatomic ligands to enhance Route [A] and to diminish Route [B], resulted in substantial (up to >10 3 -fold) decrease in the apparent O 2 -aff… Show more
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