Investigation and Analysis of Iron-Deficiency Anemia Complicated by Splenomegaly

Abstract

Objective: This study aimed to determine the incidence of iron-deficiency anemia (IDA) complicated by splenomegaly in our hospital over the past 6 years and to analyze the possible causes of this result. Methods: This is a retrospective study. In total, 668 patients with IDA who were hospitalized in the hematology department of our hospital from 2013 to 2019 were selected as the research subjects and included in the IDA group, and 3201 patients who underwent outpatient physical examinations in our hospital during the same period were included in the control group. The incidences of splenomegaly in the IDA and control groups were calculated, and the difference was analyzed by means of statistical methods. Results: Among the 668 IDA patients, 46 (6.9%) had splenomegaly, and among the 3201 patients in the control group, 21 had splenomegaly (0.7%). The incidence of splenomegaly was significantly higher in the IDA group than in the control group, and the severity of anemia in the IDA group was associated with the occurrence of splenomegaly. Specifically, the incidence of splenomegaly was 12.4% among patients with severe anemia and as high as 50% among patients with extremely severe anemia. Conclusion: IDA is correlated with the incidence of splenomegaly, and the incidence of splenomegaly significantly increases as the severity of IDA increases. This is considered to be caused by extramedullary hematopoiesis.

Effects of Exogenous Transferrin on the Regulation of Iron Metabolism and Erythropoiesis in Iron Deficiency With or Without Anemia

“…Upon iron repletion, recovery from IDA has features of stress erythropoiesis, including rapid erythropoietic expansion and reticulocytosis. Splenomegaly is evidenced in mice ( Gibson et al, 2011 ) and patients ( Wei et al, 2021 ) with severe ID, consistent with extramedullary hematopoiesis.…”

Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster

“…Accordingly, in cases of compensatory hematopoiesis outside the bone marrow, an enlarged splenic mass was frequently observed. 62,63 Our supplementation studies revealed that curcumin and BPA treatment also caused a notable decline of the F I G U R E 8 Curcumin treatment altered the polyamine pattern and the expression of genes involved in spermidine production in murine spleen tissue. Tissues derived from a former 0.2% curcumin supplementation mice study 24 were analyzed for (A) their polyamine content and (B) their transcript levels of related key genes.…”

“…However, recent studies suggest that under certain pathological conditions including iron‐deficiency anemia the spleen can be stimulated to restore hematopoietic function. Accordingly, in cases of compensatory hematopoiesis outside the bone marrow, an enlarged splenic mass was frequently observed 62,63 …”

The Impact of Body Weight on Blood Hemoglobin Level When Using Some Modern Family Planning Methods in Egypt

“…An abnormal blood hemoglobin level is one of the causes of the most severe health crises, such as strokes (Al-Harbi et al, 2020;Chang et al, 2020;Guo et al, 2019;Naess et al, 2019;Yoshimura et al, 2020), severe cognitive impairment after a stroke (He et al, 2020), cardiovascular disorders and diseases and heart attacks (Houghton et al, 2020;Park et al, 2020;Rocha et al, 2018;Sabah et al, 2020;Zhang et al, 2019), Alzheimer's and dementia risks and cognitive impairment (Kim et al, 2019;Kung et al, 2021;Shah et al, 2011;Wolters et al, 2019), blood clots (Faes et al, 2019;Gupta et al, 2019), blood diseases, such as sarcopenia leukemia (Hamamyh, and Yassin, 2020;Yoshimura et al, 2020), splenomegaly (Li et al, 2019;Majer et al, 2021;Wei et al, 2021), deterioration of kidney functions (Tsujita et al, 2019), thyroid disorders (Ahmed et al, 2021;Ghiya, and Ahmad, 2019;Islam et al, 2021), blood pressure disorders (ZHAO et al, 2023), dysphagia (Yoshimura et al, 2020), restless legs syndrome (Lyu et al, 2019;Olgun Yazar et al, 2019;Panvatvanich, and Lolekha, 2019), immunity disorders (Yang et al, 2019), risk of viral and bacterial infections, such as COVID-19 (Chowdhury, and Anwar, 2020), ulcers (Soodmand et al, 2019;Yammine et al, 2021), gout (Eun et al, 2019;…”