Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
Eugenia Radulescu,
Qiang Chen,
Giulio Pergola
et al.
Abstract:The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene co-expression network algorithms (e.g., WGCNA). To improve reliability with this method it is critical to remove unwanted sources of variance while also preserving biological signals of interest. In this WCGNA study of RNA-Seq data from postmortem prefrontal cortex (78 neurotypical donors, EUR ancestry), we tested the effects of SCZ genetic risk on co-e… Show more
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