Investigating the synergistic role of heavy metals in Arsenic-induced skin lesions in West Bengal, India

Banerjee, Shuvam; Dhar, Shrinjana; Sudarshan, M.; Chakraborty, Anindita; Bhattacharjee, Sandip; Bhattacharjee, Pritha

doi:10.1016/j.jtemb.2022.127103

Cited by 7 publications

(4 citation statements)

References 54 publications

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“…Several studies have reported elevated levels of carcinogenic heavy metals in different regions, emphasizing the need for comprehensive risk assessments and appropriate mitigation strategies 59 . The analysis of cancer risks reveals that certain counties exhibit excess lifetime cancer risks (ELCR) above the acceptable maximum risk suggested by the USEPA, which is ≤ 1 × 10 −6 (USEPA, 2021).…”

Section: Resultsmentioning

confidence: 99%

Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran

Radfard,

Hashemi,

Baghapour

et al. 2023

Sci Rep

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Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars province and evaluate the attributed burden of disease. Non-carcinogenic risk assessment was performed using the hazard quotient (HQ) method, while the carcinogenic risk assessment utilized the excess lifetime cancer risk approach. The burden of disease was evaluated in terms of years of life lost, years lived with disability, and disability-adjusted life years (DALY) for three specific cancers: skin, lung, and kidney cancer. The average drinking water concentrations of arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) were determined to be 0.72, 0.4, 1.10 and 0.72 μg/L, respectively. The total average HQ of heavy metals in drinking water in the study area were 0.127, 0.0047, 0.0009 and 0.0069, respectively. The average ILCRs of heavy metal in the entire country were in the following order: 1.15 × 10−5 for As, 2.22 × 10−7 for Cd and 3.41 × 10−7 for Cr. The results also indicated that among the various counties analyzed, Fasa experiences the greatest burden of disease in terms of DALYs, with a value of 87.56, specifically attributed to cancers caused by exposure to arsenic. Generally, it can be said that the burden of disease is a critical aspect of public health that requires comprehensive understanding and effective intervention.

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Section: Resultsmentioning

confidence: 99%

Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran

Radfard,

Hashemi,

Baghapour

et al. 2023

Sci Rep

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“…For instance, several essential trace elements such as Zn, Fe, and Se showed protective roles in Cd-induced toxicity ( 112 ). In addition, it has been shown that Pb and As have synergistic toxicity to the developing brain, leading to impaired neurobehavioral functions ( 113 ). The potential interactions between trace elements in CHDs have also been studied in several epidemiological studies, though most of the results were not significant ( 38 , 64 , 67 , 114 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

et al. 2023

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Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace elements and non-essential trace elements. Essential trace elements such as copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and manganese (Mn) play important roles in human biological functions such as metabolic function, oxidative stress regulation, and embryonic development. Non-essential trace elements such as cadmium (Cd), arsenic (As), lead (Pb), nickle (Ni), barium (Ba), chromium (Cr) and mercury (Hg) are harmful to health even at low concentrations. Recent studies have revealed the potential involvement of these trace elements in the pathogenesis of CHDs. In this review, we summarized current studies exploring exposure to essential and non-essential trace elements and risks of CHDs, in order to provide further insights for the pathogenesis and prevention of CHDs.

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“…Arsenic (As) poisoning is a significant concern in 108 countries, where it affects more than 230 million people primarily through food and drinking water [ 1 ]. In regions where people are using As-free safe drinking water, some of them are still suffering from arsenic-induced diseases including arsenicosis, cancers, hyperkeratosis, restrictive lung diseases, and ischemic heart diseases [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Groundwater As exceeding the permissible limit set by the WHO (<10 μg/L) and the FAO (100 μg/L) for irrigation and its application for rice and vegetable production poses a potential health concern worldwide [ 3 , 4 , 5 , 6 ]. Growing rice and vegetables with groundwater contaminated with As can massively increase daily dietary As intake [ 1 ]. While more than 100 countries worldwide are involved in the rice-growing practice, 90% of the world’s rice is grown in just 14 Asian countries, with groundwater serving as the primary irrigation water supply in most [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Arsenic Elevated Groundwater Irrigation: Farmers’ Perception of Rice and Vegetable Contamination in a Naturally Arsenic Endemic Area

Rokonuzzaman

2023

IJERPH

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Arsenic (As) in groundwater and its accumulation in agricultural produces has caused serious threats to human health. The majority of current research on As mainly focuses on the technical aspects while bypassing the social perspectives. Farmers are the prime stakeholders as well as executors of agricultural strategies, and their adaptation largely depends on how they perceive the risk for which a mitigation strategy is proposed. This study aims to explore how rice and vegetable farmers perceive As accumulation in their rice and vegetables as well as explore current crop- and body-loading status, the subsequent health consequences of As, and alleviation possibilities with mitigation strategies and to investigate if there is an association between their socioeconomic status and their level of perception. Results reveal that one-fourth of the farmers gave a positive message regarding the As-contamination scenario in rice and vegetables. Although 10 farmers’ socioeconomic characteristics were positively significant, distinctive emphasis should be given to five predictor variables explaining 88% variances: knowledge, direct participation in farming, information sources used, participant education, and organizational participation. Path analysis depicts that direct participation in farming presents the highest positive total effect (0.855) and direct effect (0.503), whereas information sources show the highest positive indirect effect (0.624). The mean As content in all five locations was statistically significant at the 5%, 5%, 0.1%, 1%, and 1% probability levels in scalp hairs, rice, vegetables, soils, and irrigation water, respectively. The first principal component (PC1) explains 92.5% of the variation. Significant variations were primarily explained by As levels in irrigation water, rice grain, and soil. Farmers’ perception is far behind the actual field status of As level and its transfer. Therefore, intensified priorities should be administered on the farmers’ characteristics contributing to variances in perception. The findings can be utilized for policy formulation in all As-endemic nations. More multidisciplinary research can be undertaken on farmers’ attitude towards adopting As-mitigation techniques, with a focus on the socioeconomic position found to influence farmers’ perceptions.

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Investigating the synergistic role of heavy metals in Arsenic-induced skin lesions in West Bengal, India

Cited by 7 publications

References 54 publications

Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran

Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran

Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

Arsenic Elevated Groundwater Irrigation: Farmers’ Perception of Rice and Vegetable Contamination in a Naturally Arsenic Endemic Area

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