Investigating the synergistic antimicrobial effect of carvacrol and zinc oxide nanoparticles against Campylobacter jejuni

Windiasti, Gracia; Feng, Jian; Ma, Lina; Hu, Yaxi; Hakeem, Mohammed Jamal; Amoako, Kingsley K.; Delaquis, Pascal; Lu, Xiaonan

doi:10.1016/j.foodcont.2018.08.028

Cited by 33 publications

(18 citation statements)

References 123 publications

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“…Carvacrol is the major component of oregano and thyme essential oil [48]. Many studies have shown that the antibacterial effect of carvacrol against Gram-positive bacteria is stronger than that against Gram-negative bacteria, which may be because of the fact that the cell wall of Gram-negative bacteria is covered with a membrane containing lipopolysaccharide, limiting the diffusion of hydrophobic compounds through the membrane surface [49,50].…”

Section: Antibacterialactivitymentioning

confidence: 99%

Effect of Sonication on the Properties of Flaxseed Gum Films Incorporated with Carvacrol

Fang

Qiu

Mei

et al. 2020

IJMS

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Carvacrol is a natural compound known to be a highly effective antibacterial; however, it is a hydrophobic molecule, which is a limitation to its use within food packaging. Flaxseed gum (FG) films containing different contents of carvacrol (C) were produced by a film-casting method with sonication. The effects of sonication power and time on the properties of the FG-C films were investigated by measuring the film thickness, mechanical properties, contact angle, opacity, water vapor permeability (WVP), water sorption isotherm, Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry (DSC), antibacterial and antioxidant activities, and microstructure. The results showed that sonication power and time had significant effects on mechanical and barrier properties, film opacity, and degradability (p < 0.05). The tensile strength (TS) and elongation at break (EB) values exhibited an obvious improvement after sonication, and FG-0.5C-6030 had the lowest TS (33.40 MPa) and EB (4.46%) values. FG-C films formed a denser structure and the contact angle was improved as a result of sonication, which improved the integration of carvacrol into the FG matrix. In terms of microstructure, sonication resulted in a homogeneous and continuous crosssection of FG-C films, and regular surface and cross-sectional images were obtained through the highest acoustic intensity and longest time treatment. The FG films incorporated with carvacrol displayed antibacterial properties against Staphylococcus aureus, Vibrio parahaemolyticus, Shewanella putrefaciens, and Pseudomonas fluorescens, as well as increased antioxidant properties, and sonication was proven to enhance both of them.

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Section: Antibacterialactivitymentioning

confidence: 99%

Effect of Sonication on the Properties of Flaxseed Gum Films Incorporated with Carvacrol

Fang

Qiu

Mei

et al. 2020

IJMS

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“…Moreover, using the same dosage of Ag NPs (the TEM image is shown in Figure S1) prepared without stabilized ligand or supports led to a much lower inhibition effect on both gram-negative and gram-positive bacterial strains (Figure S3), probably due to their aggregations in the liquid. Obviously, the nanocomposite demonstrated much higher antibacterial efficiency than the single pure ZIF-8 and Ag Nps (shown in Figure 6), indicating that the copresence of Ag Nps and ZIF-8 provided a synergistic effect on its antibacterial activity [16,25]. As reported by Guo et al, they also observed that the core-shell Ag@ZIF-8 nanowires exhibited much higher antibacterial activities than pure Ag nanowires and ZIF-8 [16].…”

Section: Resultsmentioning

confidence: 82%

“…As shown in Figure 5 and Figure 6, in the control tests, the pure H-ZIF-8 show little antibacterial effect on both the gram-positive bacteria, S. aureus and gram-negative, E. coli strains. Many studies have shown that the released zinc ions from Zn-based nanomaterials and/or the attachment of nanoparticles or their aggregates to the organism were responsible for their nanotoxicity [25,26,27,28,29]. The Ag NP-decorated H-ZIF-8 progressively inhibited the growth of the organism and showed a significantly enhanced antibacterial property compared to the same dose of pure H-ZIF-8.…”

Section: Resultsmentioning

confidence: 99%

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Zhang

Song

et al. 2019

Nanomaterials

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Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections.

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“…Similarly, carvacrol was combined with ZnO NP and this combination was found highly effective against Campylobacter jejuni . Moreover, it was also observed that a single treatment with one antibacterial agent, in low concentration, could show bacteriostatic effect [ 59 ]. The idea of combining essential oil with ZnO NP enabled us to use antibacterial agents in low concentrations to ensure biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

Khan

Huang

Shahriari-Khalaji

et al. 2021

Bioactive Materials

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Diabetic wound (DW) healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation. Electrospun nanofibrous (NF) membranes, due to special structural features, are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner. Herein, we report a multifunctional composite NF membrane loaded with ZnO nanoparticles (NP) and oregano essential oil (OEO), employing a new loading strategy, capable to sustainedly co-deliver bioactive agents. Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities. Furthermore, in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation. The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor (VEGF). Moreover, the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin −6 (IL-6) and matrix metalloproteinases-9 (MMP-9). In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

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Investigating the synergistic antimicrobial effect of carvacrol and zinc oxide nanoparticles against Campylobacter jejuni

Abstract: Chapter 4: Investigation of the gene expression profile of Campylobacter jejuni after treatment with carvacrol and zinc oxide nanoparticles .

Cited by 33 publications

References 123 publications

Effect of Sonication on the Properties of Flaxseed Gum Films Incorporated with Carvacrol

Effect of Sonication on the Properties of Flaxseed Gum Films Incorporated with Carvacrol

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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