Investigating the stability of electrically conductive membranes

Halali, Mohamad Amin; Larocque, Melissa; Lannoy, Charles‐François de

doi:10.1016/j.memsci.2021.119181

Cited by 35 publications

(41 citation statements)

References 58 publications

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“…The membrane fabrication method has been documented in our previous work. , In summary, a well-dispersed suspension of SWCNT/DWCNT/PVA/SDS in DI water was vacuum filtered through an MF PES membrane following CNT deposition, and the membranes were immersed in a 2.12 w/% solution of GA in DI water at 80 °C, immersed in 0.1 M HCl for 1 h, and cured in an oven for 10 min at 100 °C.…”

Section: Materials and Methodsmentioning

confidence: 99%

Quantifying the Impact of Electrically Conductive Membrane-Generated Hydrogen Peroxide and Extreme pH on the Viability of Escherichia coli Biofilms

Halali

Lannoy

2021

Ind. Eng. Chem. Res.

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Electrically conductive membranes (ECMs) self-induce antifouling mechanisms at their surface under certain applied electrical currents. Quantifying these mechanisms is critical to enhancing ECMs' self-cleaning performance. Local pH change and H 2 O 2 production are among the most important self-cleaning mechanisms previously hypothesized for ECMs. However, the impacts of these mechanisms have not previously been isolated and comprehensively studied. In this study, we quantified the individual impact of electrochemically induced acidic conditions, alkaline conditions, and H 2 O 2 concentration on model bacteria, Escherichia coli. To this end, we first quantified the electrochemical potential of carbon nanotube-based ECMs to generate stressors, such as protons, hydroxyl ions, and H 2 O 2 , under a range of applied electrical currents (±0−150 mA, 0−2.7 V). Next, these chemical stressors with similar magnitude to that generated at the ECM surfaces were imposed on E. coli cells and biofilms. In the flow-through ECM systems, biofilm viability using LIVE/DEAD staining indicated biofilm viabilities of 39 ± 9.9%, 38 ± 4.7%, 45 ± 5.0%, 34 ± 3.1%, and 75 ± 4.9% after separate exposure to pH 3.5, anodic potential (2 V), pH 11, cathodic potential (2 V), and H 2 O 2 concentration (188 μM). Electrical current-induced pH change at the membrane surface was shown to be more effective in reducing bacterial viability than H 2 O 2 generation and more efficient than bulk pH changes. This study identified antibiofouling mechanisms of ECMs and provides guidance for determining the current patterns that maximize their antifouling effects.

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Section: Materials and Methodsmentioning

confidence: 99%

Quantifying the Impact of Electrically Conductive Membrane-Generated Hydrogen Peroxide and Extreme pH on the Viability of Escherichia coli Biofilms

Halali

Lannoy

2021

Ind. Eng. Chem. Res.

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“…Detailed experiments as well as the results of surface conductivity, mechanical conductivity, and chemical bonding state of membranes with different networks are provided in the original manuscript [1] . ECM conductivity measurements before and after surface oxidation (not shown here) revealed that the ECM surface conductivity was lower for all ECMs after oxidation, supporting the results from chronoamperometry.…”

Section: Methods Validationmentioning

confidence: 99%

“…The mechanical breakdown of CNT structures was quantified using a total organic carbon analyzer and found to be insignificant. FTIR analysis, found in the supplementary information of the original manuscript [1] , was conducted to monitor the presence of chemical bond formation in response to a current applied to the ECMs. The presence of C=O bonds increased during electrochemical oxidation.…”

Section: Methods Validationmentioning

confidence: 99%

“…The results of induced concentration polarization were discussed in detail in the original manuscript [1] . As explained in the Methods section, a series of control tests were conducted to assess the stability of the nanolayer followed by deconvolution of leaching sources as follows: 2 MDa PEO separation test on pristine PES membrane: Negligible carbon content in the permeate side 2 MDa PEO separation test on PES membrane exposed to the processing conditions used in making the ECMs, including high temperature curing and acidic solutions: Negligible carbon content in the permeate side Pure water flux on PES membranes and ECMs: Negligible carbon content in the permeate side 2 MDa PEO separation test on ECMs containing PVA: High carbon content observed in the permeate side …”

Section: Methods Validationmentioning

confidence: 99%

“…A summary of leachate values quantified from different rejection tests is provided in Table 4 [ 1 , 41 ]. In short, UF PES membranes fully rejected 2 MDa PEO particles (99.6%).…”

Section: Methods Validationmentioning

confidence: 99%

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Methods for stability assessment of electrically conductive membranes

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Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood circulation. Upon entry into the cell, specific components of the lipid nanoparticles can promote the endosomal escape of nucleic acids. These are the basic properties of lipid nanoparticles as nucleic acid carriers. As LNPs exhibit hepatic aggregation characteristics, enhancing targeting out of the liver is a crucial way to improve LNPs administrated in vivo. Meanwhile, endosomal escape of nucleic acids loaded in LNPs is often considered inadequate, and therefore, much effort is devoted to enhancing the intracellular release efficiency of nucleic acids. Here, we concluded different strategies to efficiently deliver nucleic acid delivery from LNPs and investigated their mechanisms. In addition, based on the information on LNPs that are in clinical trials or have completed clinical trials, we discussed the issues that are necessary to be approached in the clinical translation of LNPs, which we hope will shed light on the development of LNP nucleic acid drugs.This article is protected by copyright. All rights reserved

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Investigating the stability of electrically conductive membranes

Cited by 35 publications

References 58 publications

Quantifying the Impact of Electrically Conductive Membrane-Generated Hydrogen Peroxide and Extreme pH on the Viability of Escherichia coli Biofilms

Quantifying the Impact of Electrically Conductive Membrane-Generated Hydrogen Peroxide and Extreme pH on the Viability of Escherichia coli Biofilms

Methods for stability assessment of electrically conductive membranes

Lipid Nanoparticles Optimized for Targeting and Release of Nucleic Acid

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