Investigating the Role of Zinc in a Rat Model of Epilepsy

Baraka, Azza; Nabi, W. Hassab El; Ghotni, S. El

doi:10.1111/j.1755-5949.2011.00252.x

Cited by 23 publications

(16 citation statements)

References 53 publications

(64 reference statements)

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“…This controversy may be a result of differences in zinc rout administration and difference in sensitivity of these patients in response to zinc components. Since Zn is a voltage sensitive calcium channels blocker and has antiepileptic role in appropriate doses [25,26], it may be blocked prolactin inhibitor factor secretion in hypothalamus and caused increased prolactin secretion in adenohypophsis [27,28]. Moreover, present results showed that serum LH level was decreased in experimental group but did not show any changes in serum FSH level.…”

Section: Discussionsupporting

confidence: 53%

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

Shahraki

Forghani

Mohammadi

et al. 2015

Zahedan J Res Med Sci

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Background:Zn is calcium channels blocker and interferes with biological function of calcium ion, and FSH and LH secretion are dependent on calcium ion. Objectives: The aim of this study was evaluate the effects of supra physiological dose of zinc injection in lateral ventricle (LV) on serum FSH, LH, testosterone, and prolactin (PRL) in male rats. Materials and Methods: This experiment was performed on 30 Wistar-Albino male rats weighing 220 -260 g, which were cannulated in LV. Rats were divided into: sham control (SC), control (V), and test (T) groups, randomly. Test group received 10 µL of artificial cerebra spinal fluid (ACSF) containing 0.06 μmol zinc sulfate, for 20 days. Group V was given the same volume of ACSF, but group SC did not receive any agent at this time. At the end, animals were anesthetized by diethyl ether, sacrificed and blood samples were collected. Serum gonadotropins and prolactin were measured via rat kits and ELISA methods. Testosterone was measured by ordinary methods. Obtained data were analyzed by SPSS-17 software and Kruskal-Wallis, Mann-Whitney and Bonnferoni correction statistical tests. Results were expressed as mean ± SD. Statistical differences were recognized significant at P < 0.05. Results: Our findings showed that serum LH, food and weight gain in group T significantly decreased but prolactin value in this group increased in comparison to those in other groups. Conclusions: We conclude that intraventricular (IV) injection of supra physiological dose of zinc sulfate in IV affected on serum LH, prolactin, food intake, and gain of weight in male rats.

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Section: Discussionsupporting

confidence: 53%

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

Shahraki

Forghani

Mohammadi

et al. 2015

Zahedan J Res Med Sci

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“…In addition, it has been proposed that zinc could have a neurotoxic role where excessive zinc could impair the protein degradation pathway and might be a crucial factor mediating neuronal death [202]. In line with this, another study demonstrated that the pretreatment with a high dose of zinc exacerbated pilocarpine-induced seizures, whereas a medium dose of zinc reduced the severity of limbic seizures [203]. In appropriate doses, zinc plays an important role in mitigating seizures by suppressing oxidative stress, apoptotic activity and IL-1β levels, resulting in neuroprotective effects [203].…”

Section: Zinc Seizures and Epilepsymentioning

confidence: 83%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide. However, despite the continuous development of antiepileptic drugs, over 30% patients with epilepsy progress to drug-resistant epilepsy. For this reason, it is a high priority objective in preclinical research to find novel therapeutic targets and to develop effective drugs that prevent or reverse the molecular mechanisms underlying epilepsy progression. Among these potential therapeutic targets, we highlight currently available information involving signaling pathways (Wnt/β-catenin, Mammalian Target of Rapamycin (mTOR) signaling and zinc signaling), enzymes (carbonic anhydrase), proteins (erythropoietin, copine 6 and complement system), channels (Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy. Although some research with these specific targets has been done in relation with epilepsy, they have not been fully explored as potential therapeutic targets that could help address the unsolved issue of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.

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“…The PTZ test identifies drugs with efficacy against generalized nonconvulsive seizures . The pilocarpine‐treated rat model is also adopted in many studies , and the changes along with NMDAR upregulation in parahippocampal areas such as the EC have been reported in this model . In the low‐Mg 2+ /high‐K + ‐induced epilepsy model, the generation of SLEs has been attributed to the reduced surface charge of neuronal membrane and the disinhibition of NMDAR followed by calcium influx .…”

Section: Discussionmentioning

confidence: 99%

Aggravation of Seizure‐like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability

Luo

Zhou

et al. 2014

CNS Neurosci Ther

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Investigating the Role of Zinc in a Rat Model of Epilepsy

Abstract: The present study highlights the antiepileptic role that could be played by Zn, when given in appropriate doses.

Cited by 23 publications

References 53 publications

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Aggravation of Seizure‐like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability

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