Abstract:Pairing an environmental context with repeat opioid use (ROU) can result in increased tolerance to the effects of the opioid. This context-dependent tolerance has been extensively studied with respect to the analgesic effects of opioids, yet a knowledge gap exists in understanding whether there is context-dependent tolerance that develops in opioid induced respiratory depression (OIRD). While activity in the Locus Coeruleus (LC), the primary noradrenergic center of the brain, is involved in cue-reward related … Show more
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