Investigating the role of ATP towards amplified peroxidase activity of Iron oxide nanoparticles in different biologically relevant buffers

Vallabani, N.V. Srikanth; Singh, Sanjay; Karakoti, Ajay

doi:10.1016/j.apsusc.2019.06.177

Cited by 19 publications

(15 citation statements)

References 62 publications

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“…However, after adding H 2 O 2 , the bright blue color could be observed. Moreover, compared with FePNPs, the presence of GMP increased the catalytic activity of FeGPNPs, consistent with the previous reports that use of nucleotides improve the peroxidase activity displayed by iron oxide and other particles [ 35 , 36 ]. More specifically, FeGPNPs exhibited significant catalytic activity in a concentration- and time-dependent manner (Fig.…”

Section: Resultssupporting

confidence: 91%

Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Wang

Chen

et al. 2022

J Nanobiotechnol

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Background Ferroptosis holds promise as a potential tumor therapy by programming cell death with a hallmark of reactive oxygen species (ROS)-induced lipid peroxidation. However, vigorous energy metabolism may assist tumors to resist oxidative damage and thus weaken the effects of ferroptosis in tumor treatment. Results Herein, a bifunctional antitumor platform was constructed via coordinated interactions between metal ions and nucleotides to synergistically activate ferroptosis and interrupt energy metabolism for tumor therapy. The designed nanoparticles were composed of Fe2+/small interfering RNA (siRNA) as the core and polydopamine as the cloak, which responded to the tumor microenvironment with structural dissociation, thereby permitting tumor-specific Fe2+ and siRNA release. The over-loaded Fe2+ ions in the tumor cells then triggered ferroptosis, with hallmarks of lipid peroxidation and cellular glutathione peroxidase 4 (GPX4) down-regulation. Simultaneously, the released siRNA targeted and down-regulated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in the tumor to inhibit glycolytic pathway, which interfered with tumor energy metabolism and enhanced Fe2+-induced ferroptosis to kill tumor cells. Conclusions This study presents a concise fabrication of a metal ion/nucleotide-based platform to integrate ferroptosis and energy metabolism intervention in one vehicle, thereby providing a promising combination modality for anticancer therapy. Graphical Abstract

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Section: Resultssupporting

confidence: 91%

Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Wang

Chen

et al. 2022

J Nanobiotechnol

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“…Similar enhanced activities of the peroxidase activity of magnetite and gold nanoparticles were recently reported. [61][62][63] Oxidase activity of bare and coated CNPs was also evaluated at concentration of 250 nM and revealed an overall decrease of the activity in presence of the polymers (Supplementary Information S6). The TMB can be oxidized by superoxide or hydroxyl radicals and it is important to differentiate whether the peroxidase activity is due to the production of hydroxyl radicals OH…”

Section: 𝑣([𝑇𝑀𝐵]) = 𝑉 -Fg [𝑇𝑀𝐵] 𝐾 -+ [𝑇𝑀𝐵]mentioning

confidence: 99%

Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts

Baldim

Yadav

Bia³

et al. 2020

ACS Appl. Mater. Interfaces

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101

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Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, harmful molecules produced in oxidative stress associated diseases. Despite the fact that nanoparticle functionalization is mandatory in the context of nanomedicine, the influence of polymer coatings on their enzyme-like catalytic activity is poorly understood. In this work, six polymer coated cerium oxide nanoparticles are prepared by association of 7.8 nm cerium oxide cores with two poly(sodium acrylate) and four poly(ethylene glycol) (PEG) grafted copolymers with different terminal or anchoring end groups, such as phosphonic acids. The superoxide dismutase-, catalase-, peroxidase-and oxidase-like catalytic activities of the coated nanoparticles were systematically studied. It is shown that the polymer coatings do not affect the superoxide dismutase-like, impair the catalase-like and oxidase-like and surprisingly improves peroxidase-like catalytic activities of cerium oxide nanoparticles. It is also demonstrated that the particles coated with the PEG-grafted copolymers perform better than the poly(acrylic acid) coated ones as oxidoreductase-like enzymes, a result that confirms the benefit of having phosphonic acids as anchoring groups at the particle surface.

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“…From this result, we confirmed the high selectivity of Cu 2+ @POP to both AA and DA. We compare this with various nanozymes mentioned in the literature [49][50][51][52][53] and listed in Table 1.…”

Section: Selectivity Of Aa and Da Detectionmentioning

confidence: 99%

Transition metal ion-coordinated porous organic polymer to enhance the peroxidase mimic activity for detection of ascorbic acid and dopamine

Marieeswaran

Panneerselvam

2022

Mater. Adv.

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Investigating the role of ATP towards amplified peroxidase activity of Iron oxide nanoparticles in different biologically relevant buffers

Cited by 19 publications

References 62 publications

Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts

Transition metal ion-coordinated porous organic polymer to enhance the peroxidase mimic activity for detection of ascorbic acid and dopamine

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