Investigating the role of a testis-expressed gene Tex2 in spermatogenesis in mice
Suyan Wang,
Dingming Li,
Gan Shen
et al.
Abstract:Background
Although TEX2 is primarily expressed in the testes of mammals, its exact role in reproduction remains unclear. This study aims to explore whether TEX2 plays a role in determining fertility in mice.
Methods
To address this issue, a mouse model with Tex2 knockout was created through CRISPR/Cas9 technology. Various experiments, including qPCR, Western blotting, immunofluorescence, electron microscopy, CASA, and H&E staining, were conducted to evaluate the role of TEX2 on mouse spermatogenesis.
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