Fragility analysis is essential for assessing structural vulnerability during natural hazards like earthquakes and floods. It guides risk mitigation, enhances infrastructure resilience, and informs decision-making, emergency planning, and disaster recovery efforts. This manuscript aims to explore the fragility curves potential in assessing the structural systems performance, particularly those with high irregularity. The study employs a non-linear static analysis of a G+6 storey irregular structural frame designed in accordance with Indian standards using SAP2000. It demonstrates the use of fragility curves in assessing structural performance of a G+6 irregular reinforced concrete structure under earthquake forces. This manuscript underscores the importance of considering discrete damage probabilities and collapse risks in different directions for accurately assessing structural vulnerabilities. It reveals a higher collapse probability within the direction of push-y (44%) in contrast with the push x-direction (5%), indicating a greater susceptibility to damage under specific loading conditions. The study concludes that fragility curves offer a rational and consistent method for seismic performance assessment of structures with high irregularity. It also affirms the adequacy of buildings designed as per Indian standards in withstanding earthquake forces.