This study was conducted to determine the rate and risk factors of computer game addiction and its relation with the quality of life in preadolescents. Material and Methods: The sample of this descriptive and cross-sectional study consisted of 439 (n girls =239, n boys =200) preadolescents. Data were collected using a family and child information form, the Computer Game Addiction Scale for Children (CGASC), and the Pediatric Quality of Life Inventory child form. Data were assessed using descriptive statistics, the independent samples t-test, one-way analysis of variance (Post-hoc Tukey), Pearson correlation, and univariate and multiple logistic regression analysis. Results: According to the CGASC scores of the preadolescents, 12.8% were determined as "risky users". Multiple binary logistic regression analysis results revealed the most important factors affecting the possibility of preadolescents' becoming risky users for computer game addiction as gender, weekend computer gaming duration (hours/day), and the quality of life scores (p<0.01). There was a negative, weak and (p<0.001) significant relationship between computer game addiction scores and quality of life scores of preadolescents. The increase in quality of life scores of preadolescents decreased the possibility of being a "risky user" in terms of computer game addiction (p<0.001). Conclusion: It is recommended to attempt to increase the quality of life of preadolescents in order to protect them from computer game addiction.