Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using raman spectroscopy and mapping**Maike Windbergs and Miriam Haaser contributed equally to this work.

Raman spectroscopy of lipids: a review

“…80% of TMA, has been used as a counter‐irritant and in a treatment of rheumatism. TPA is used as a good matrix component for the manufacturing of solid lipid extrudates, whereas TSA is approved as a food additive, as crystallization accelerator in cocoa products and to make soaps, candles, waterproofing paper etc …”

Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill

“…It is known that finely dispersed drug particles in a mixture can also lead to an enhanced dissolution rate because of a reduced agglomeration tendency; therefore, further investigations focused on bulk dispersity. Confocal Raman microscopy is a chemically selective analytical technique allowing label‐free detection of drug and excipient distribution within solid carrier systems . Here, confocal Raman microscopy was applied to evaluate dispersity differences of griseofulvin particles within the different compacts prepared from physical mixtures and the coground formulation.…”

Vibrational analysis of cinchona alkaloids in the solid state and aqueous solutions

“…One of the most efficient techniques in studies on spatial distribution of active pharmaceutical components (APIs) in drugs is Raman mapping. An increasing availability of Raman spectrometers equipped with confocal microscopes and CCD detectors allows for solving of many problems such as the three‐dimensional distribution of an amorphous domain within a crystalline sample, drug diffusion through membranes, pharmaceutical distribution within cells, controlled drug release, enhancing API solubility, and effects of manufacturing methods . On the other hand, Raman mapping measurements in macro scale allow for investigations of areas of even more than 100 mm 2 …”