Investigating the relationship between body composition, lifestyle factors, and anti-Müllerian hormone serum levels in women undergoing infertility assessment

Mitchell, J; Fee, Niamh; Roopnarinesingh, R; Mocanu, Edgar

doi:10.1007/s11845-022-03148-x

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Among lifestyle variables, never/seldom or less than 2-items vegetable intake per day was associated with a lower level of AMH in poor-responders in the nal analysis. Overall, ndings indicated that AMH levels are in uenced by lifestyle [11,12]. In agreement our study, F. Foroozanfard et al have been found a bene cial effects of dietary pattern on AMH levels [13].…”

Section: Discussionsupporting

confidence: 91%

“…Among poor-responder women, low level of AMH and a reduced ovarian reserve can become a critical factor in infertility, without any obvious clinical symptoms. There were several nomograms for clinical interpretation of AMH levels in different groups (7)(8)(9)(10)(11)(12). Nevertheless, there are recommendations that AMH varies according to socio-economic status (SES), lifestyle and fertility characteristics casting doubt on the clinical utility of these nomograms [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Müllerian Hormone (AMH) level in poor-responder women and its correlates with lifestyle and socio-demographic characteristics

Hakimi,

Tabatabaei,

Namin

et al. 2023

Preprint

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Background Anti-Mullerian hormone (AMH) is an indicator of women ovarian reserve or the number of follicles remaining in a woman's ovaries. Unlike other groups of women, AMH level is poorly understood in poor-responders women. We aimed to investigate AMH level in poor-responder women and how it’s related to reproductive factors, lifestyle and socio-demographic characteristics. Methods A total of 119 poor-responder women were randomly selected from the infertility clinic of Al-Zahra Hospital, Tabriz, in 2022. Lifestyle and reproductive factors were measured using trained interviews and valid instruments. Linear regression analysis was carried out to estimate predictors of AMH level among poor-responder women in the presence of effective factors. Results There was a significant negative correlation between advanced age (year) and AMH level (r= -0.35, P = 0.001). After adjusting for the potential confounders, advanced age (β= -0.162), never/seldom (β= -0.199), and less than 2-items (β= -0.041) vegetable intake per day were significantly decreased AMH levels among poor-responder women (P < 0.05). Furthermore, passive smoking; never/seldom and low physical activity levels decreased AMH levels but no significantly. Conclusion The study found that AMH level was associated with age and lifestyle factors among poor-responder women. Lifestyle promotion can help to improve poor-responder women's ovarian reserve and the likelihood of fertility.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian Hormone (AMH) level in poor-responder women and its correlates with lifestyle and socio-demographic characteristics

Hakimi,

Tabatabaei,

Namin

et al. 2023

Preprint

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“…Several previous studies have suggested increased risk for diminished ovarian reserve with smoking [ 1 , 2 , 5 – 10 ], but results have been inconsistent. Recent studies did not find a significant association between smoking and biomarkers of ovarian reserve [ 53 – 55 ]. These studies were limited by small sample size and did not control for PCOS status.…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies have suggested increased risk for diminished ovarian reserve with smoking [1, 2, 5-10], but results have been inconsistent. Recent studies did not find a significant association between smoking and biomarkers of ovarian reserve [53][54][55]. These studies , where a significant association between smoking and age-specific serum AMH was found for 10-15 pack-years (β = -7.0, p = 0.003) and 15-20 pack-years (β = -8.5, p = 0.001) pack-years but not for 5-10 pack-years (β = -3.1, p = 0.15) [6].…”

Section: Discussionmentioning

confidence: 99%

Association between cigarette smoking and ovarian reserve among women seeking fertility care

et al. 2022

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Introduction This study examined the association of smoking with ovarian reserve in a cross-sectional study of 207 women enrolled in the Louisville Tobacco Smoke Exposure, Genetic Susceptibility, and Infertility (LOUSSI) Study and assessed effect modification by NAT2 acetylator phenotype. Methods Information on current smoking status was collected using a structured questionnaire and confirmed by cotinine assay. Serum anti-Müllerian hormone (AMH) levels were used to assess ovarian reserve. Diminished ovarian reserve (DOR) was defined as AMH <1ng/mL. Single nucleotide polymorphisms in the NAT2 gene, which metabolizes toxins found in cigarette smoke, were analyzed to determine NAT2 acetylator status. Linear and logistic regression were used to determine the effects of smoking on ovarian reserve and evaluate effect modification by NAT2. Regression analyses were stratified by polycystic ovary syndrome (PCOS) status and adjusted for age. Results Current smoking status, either passive or active as measured by urinary cotinine assay, was not significantly associated with DOR. For dose-response assessed using self-report, the odds of DOR increased significantly for every additional cigarette currently smoked (Odds ratio, OR:1.08; 95% confidence interval, 95%CI:1.01–1.15); additionally, every 1 pack-year increase in lifetime exposure was associated with an increased odds of DOR among women without PCOS (OR: 1.08 95%CI: 0.99–1.18). These trends appear to be driven by the heavy or long-term smokers. Effect modification by NAT2 genotype was not established. Conclusion A history of heavy smoking may indicate increased risk of diminished ovarian reserve.

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A systematic review of the association between modifiable lifestyle factors and circulating anti-Müllerian hormone

Werner,

van der Schouw,

de Kat

2024

Human Reproduction Update

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BACKGROUND Levels of anti-Müllerian hormone (AMH) are known to be associated with lifestyle determinants such as smoking and oral contraception (OC) use. When measuring AMH in clinical practice, it is essential to know which factors may influence circulating levels or ovarian reserve in general. OBJECTIVE AND RATIONALE To date, there is no systematic review or summarizing consensus of the nature and magnitude of the relation between AMH and modifiable lifestyle factors. The purpose of this review was to systematically assess the evidence on association of lifestyle behaviors with circulating AMH levels. SEARCH METHODS We performed a pre-registered systematic review of publications in Embase and PubMed on the lifestyle factors BMI, smoking, OC use, alcohol consumption, caffeine consumption, physical activity, and waist–hip ratio (WHR) in relation to circulating AMH levels up to 1 November 2023. The search strategy included terms such as ‘Anti-Mullerian hormone’, ‘lifestyle’, and ‘women’. Studies were considered eligible if the association between at least one of the lifestyle factors of interest and AMH was assessed in adult women. The quality of included studies was assessed using the Study Quality Assessment Tools of the National Heart, Lung, and Blood Institute. The results were presented as ranges of the most frequently used association measure for studies that found a significant association in the same direction. OUTCOMES A total of 15 072 records were identified, of which 65 studies were eligible for inclusion, and 66.2% of the studies used a cross-sectional design. The majority of studies investigating BMI, smoking, OC use, and physical activity reported significant inverse associations with AMH levels. For WHR, alcohol, and caffeine use, the majority of studies did not find an association with AMH. For all determinants, the effect measures of the reported associations were heterogeneous. The mean difference in AMH levels per unit increase in BMI ranged from −0.015 to −0.2 ng/ml in studies that found a significant inverse association. The mean difference in AMH levels for current smokers versus non-smokers ranged from −0.4 to −1.1 ng/ml, and −4% to −44%, respectively. For current OC use, results included a range in relative mean differences in AMH levels of −17% to −31.1%, in addition to a decrease of 11 age-standardized percentiles, and an average decrease of 1.97 ng/ml after 9 weeks of OC use. Exercise interventions led to a decrease in AMH levels of 2.8 pmol/l to 13.2 pmol/l after 12 weeks in women with polycystic ovary syndrome or a sedentary lifestyle. WIDER IMPLICATIONS Lifestyle factors are associated with differences in AMH levels and thus should be taken into account when interpreting individual AMH measurements. Furthermore, AMH levels can be influenced by the alteration of lifestyle behaviors. While this can be a helpful tool for clinical and lifestyle counseling, the nature of the relation between the observed differences in AMH and the true ovarian reserve remains to be assessed. REGISTRATION NUMBER PROSPERO registration ID: CRD42022322575

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Investigating the relationship between body composition, lifestyle factors, and anti-Müllerian hormone serum levels in women undergoing infertility assessment

Cited by 6 publications

References 31 publications

Anti-Müllerian Hormone (AMH) level in poor-responder women and its correlates with lifestyle and socio-demographic characteristics

Anti-Müllerian Hormone (AMH) level in poor-responder women and its correlates with lifestyle and socio-demographic characteristics

Association between cigarette smoking and ovarian reserve among women seeking fertility care

A systematic review of the association between modifiable lifestyle factors and circulating anti-Müllerian hormone

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