Investigating the relation between the secondary yield enhancement and the structure of the metallic overlayer in metal‐assisted SIMS

Nittler, Laurent; Delcorte, Arnaud; Bertrand, Patrick; Migeon, H.-N.

doi:10.1002/sia.3425

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…We have shown that an enlarged-AuNP surface is useful to increase the SIMS intensity of surface-immobilized peptides, due to a higher binding density of analyte and relevant signal enhancement. Although other SI-enhancing methods have been developed, − our study also showed that the SIMS intensity of peptide on the enlarged AuNP was 25-fold higher than that on the AuNP surface at the highest peptide concentration, as in Figures D and . Although the signal enhancement was considerably little (only a factor of 2 higher) when compared to that on the bare Au, the use of AuNPs has more advantages over the bare Au that requires the labor-intensive evaporating steps, because the AuNP-enlarging surface is easily made from as-prepared AuNPs and subsequent chemical treatment, leading to a larger gold surface area in a nanoscale structure.…”

Section: Resultsmentioning

confidence: 58%

Secondary Ions Mass Spectrometric Signal Enhancement of Peptides on Enlarged-Gold Nanoparticle Surfaces

Kim¹,

Lee²

2012

Anal. Chem.

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A high surface coverage of gold nanoparticles (AuNPs) is a prerequisite for enhancing the peptide signal intensity in time-of-flight secondary ion mass spectrometry (TOF-SIMS). Here, we demonstrate the TOF-SIMS signal amplification of peptides on a surface by enlarging surface-confined AuNPs using the NH(2)OH/Au(3+) seeding method. Because of the increased surface area and spherical structure of the Au, the SIMS intensity of the peptides became significantly enhanced on the enlarged-AuNPs surface, especially at high concentrations of peptide solution (>10 μM), compared to that of the bare gold surface or submonolyer of AuNPs. We are confident that this will be a useful method for diagnosis and bioassay with high sensitivity in a label-free manner.

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Section: Resultsmentioning

confidence: 58%

Secondary Ions Mass Spectrometric Signal Enhancement of Peptides on Enlarged-Gold Nanoparticle Surfaces

Kim¹,

Lee²

2012

Anal. Chem.

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“…It was indicated that real Au deposition was not homogeneous, but island growth. In addition, deposited Au is considered to make threedimensional nanostructure according to the Volmer-Weber growth mechanism [9] As stated previously, cross-sectioning with the Au plate was performed, and gold was deposited onto the analyzed sections with every sectioning event. Furthermore, increased scanning of the upper section enabled an increase in Au deposition.…”

Section: Resultsmentioning

confidence: 99%

Metal‐assisted SIMS for three‐dimensional analysis using shave‐off section processing

Yamazaki

Tobe

Akiba

et al. 2014

Surface & Interface Analysis

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Three-dimensional microanalysis of the microstructure of organic materials is important in the development and progress of analytical methods on the micro-to-nanometer scales. We have developed a novel three-dimensional microanalysis method using focused ion beams for section processing (shave-off scanning) and time-of-flight secondary ion mass spectrometry for mapping. Shave-off scanning can effectively create an arbitrary section on a sample set against composites materials with a wide variety of shapes; three-dimensional sample images are then obtained by alternately operating two focused ion beams. In this study, we adapted metal-assisted secondary ion mass spectrometry for three-dimensional microanalysis. We have devised a unique method whereby gold is deposited on a section to be analyzed after every shave-off sectioning by setting a gold plate at the back of the sample. Consequently, gold was observed to be deposited on the created cross-section concurrently with shave-off sectioning, resulting in a substantially enhanced secondary ion intensity.

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“…A nominal thickness of 2 nm Ag was evaporated onto spin‐coated PS samples for the MetA‐SIMS sample configuration. It has been shown that such small amounts of noble metals deposited onto organic substrates form nano‐islands on the surface because the binding forces among the metal atoms are stronger than those between a metal atom and the organic material . There seems to be either a diffusion of metal particles into the polymer bulk or a migration of organic molecules over the metal clusters .…”

Section: Sample Preparation and Experimental Setupmentioning

confidence: 99%

The Storing Matter technique applied to polystyrene: a study of different methods to enhance Ag‐cationization

Becker¹,

Wirtz²,

Migeon³

2012

Surface & Interface Analysis

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The Storing Matter technique is derived from secondary ion mass spectrometry (SIMS) and consists in decoupling the sputtering of the specimen from the analysis step. In a dedicated prototype instrument, the sample surface is bombarded by an ion beam, and the sputtered particles are deposited at sub-monolayer level onto a collector. In a second step, this deposit is analyzed by SIMS (static or dynamic). In this work, we applied the Storing Matter technique to different types of polystyrene (PS) samples: a layer of PS spin-coated on a silicon wafer, the same sample covered with a thin Ag coating and a thin PS layer on an Ag substrate. These samples were sputter-deposited onto Si and Ag collectors in the Storing Matter prototype instrument. These deposits as well as the initial PS-based samples were analyzed by time-of-flight-SIMS conditions in positive mode. We compared the intensities of Ag-cationized oligomers for the different sample/collector combinations. The abundance and the intensities of Ag-cationized PS fragments detected in a Storing Matter deposit depend more strongly on the collector material than on the sample configuration used for sputter-deposition. For the deposits on Si collectors, almost no Ag-cationized peaks were detected, although such species are present in the positive mass spectra recorded directly on the Ag-containing PS samples. In the case of Ag collectors, Ag-cationized adducts were detected up to m/z = 1500. It seems that their abundance is mainly determined by the sputtering efficiency of large fragments during the sputter-deposition step.

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Investigating the relation between the secondary yield enhancement and the structure of the metallic overlayer in metal‐assisted SIMS

Cited by 8 publications

References 28 publications

Secondary Ions Mass Spectrometric Signal Enhancement of Peptides on Enlarged-Gold Nanoparticle Surfaces

Secondary Ions Mass Spectrometric Signal Enhancement of Peptides on Enlarged-Gold Nanoparticle Surfaces

Metal‐assisted SIMS for three‐dimensional analysis using shave‐off section processing

The Storing Matter technique applied to polystyrene: a study of different methods to enhance Ag‐cationization

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