Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced &lt;em&gt;In Vitro&lt;/em&gt; Model

Wen, Xingjian; Wang, Jia; Fan, Jiuyu; Chu, Rui; Chen, Yilong; Xing, Y.; Li, Na; Wang, Guixue

doi:10.3791/64816

Cited by 4 publications

(4 citation statements)

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“…And the phosphorylation of JNK and c-Jun played an essential role in the underlying molecular mechanism. Wen et al (2022) also found that PD ameliorated NAFLD in vitro by reducing oxidative stress and stimulating autophagy.…”

Section: Pharmacology Of Pldmentioning

confidence: 86%

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The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

et al. 2023

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Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields.

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Section: Pharmacology Of Pldmentioning

confidence: 86%

“…The intestine is very susceptible to CP chemotherapy, and the intestinal toxicity caused by CP widely affects gastrointestinal function. Fan et al (2022) found that PD can restore the intestinal mechanicalbarrier by reducing endoplasmic reticulum stress-mediated apoptosis, which might be related to PERK-eIF2ɑ-ATF4 signaling pathway.…”

Section: Organ Protectionmentioning

confidence: 93%

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

et al. 2023

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“…After treating the cells with PD (1 μmol/L) for 24 h, the levels of ROS and protein expression of p62 were significantly reduced, while the ratio of microtubule-associated proteins light chain 3 (LC3) −phosphatidylethanolamine conjugate to cytosolic form was increased. These results indicated that PD improves NAFLD by reducing oxidative stress and cellular autophagy, thereby protecting the liver ( Wen et al, 2022 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 96%

Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review

Zhang,

Wang,

Zhang

et al. 2024

Chinese Herbal Medicines

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“…Wen et al found treatment of free fatty acids to HepaRG cells in a MPS resulted in induced lipid accumulation in the cells as well as an increase in apoptotic cells. 104 The accumulation of fat in the cells induces hepatocellular stress, injury, and death. This can lead to fibrogenesis and genomic instability making the liver susceptible to cirrhosis hepatocellular carcinoma.…”

Section: The Innate Immune System and Metabolic Tissuesmentioning

confidence: 99%

Modelling the innate immune system in microphysiological systems

Rupar,

Hanson,

Rogers

et al. 2024

Lab Chip

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Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced <em>In Vitro</em> Model

Cited by 4 publications

References 0 publications

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review

Modelling the innate immune system in microphysiological systems

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