Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics

Huang, JingYi; Cao, XiaoYu; Wu, WenFeng; Han, Liang; Wang, FengYun

doi:10.1016/j.biopha.2024.116855

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116855

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Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics

JingYi Huang,

XiaoYu Cao,

WenFeng Wu

et al.

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Applications of plant‐derived extracellular vesicles in medicine

Zhu,

Zhao,

Ding

et al. 2024

MedComm

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Plant‐derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the therapeutic potential of plant‐derived EVs and emphasizes their anti‐inflammatory, antimicrobial, and tumor‐inhibitory effects. Here, we discussed the advancements in isolation and purification techniques, such as ultracentrifugation and size‐exclusion chromatography, which are critical for maintaining the functional integrity of these nanovesicles. Next, we investigated the diverse administration routes of EVs and carefully weighed their respective advantages and challenges related to bioavailability and patient compliance. Moreover, we elucidated the multifaceted mechanisms of action of plant‐derived EVs, including their roles in anti‐inflammation, antioxidation, antitumor activity, and modulation of gut microbiota. We also discussed the impact of EVs on specific diseases such as cancer and inflammatory bowel disease, highlighting the importance of addressing current challenges related to production scalability, regulatory compliance, and immunogenicity. Finally, we proposed future research directions for optimizing EV extraction and developing targeted delivery systems. Through these efforts, we envision the seamless integration of plant‐derived EVs into mainstream medicine, offering safe and potent therapeutic alternatives across various medical disciplines.

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Applications of plant‐derived extracellular vesicles in medicine

Zhu,

Zhao,

Ding

et al. 2024

MedComm

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Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics

Cited by 1 publication

References 62 publications

Applications of plant‐derived extracellular vesicles in medicine

Applications of plant‐derived extracellular vesicles in medicine

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