Investigating the prognostic ability of health-related quality of life on survival: a prospective cohort study of adults with lung cancer

Pinheiro, Laura C.; Reeve, Bryce B.

doi:10.1007/s00520-018-4265-3

Cited by 20 publications

(20 citation statements)

References 19 publications

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“…In a previous multinational review of tools for geriatric assessment, investigators found older cancer patients often weight quality of life higher than survival, compared to younger patients (37). HRQOL has also shown to be associated with earlier prognosis independent of other outcomes, emphasizing the importance of HRQOL assessment across the cancer trajectory (38,39). One strength of our study was the use of SEER linked data, which gave us access to a population-based, high-quality source of data.…”

Section: Discussionmentioning

confidence: 98%

Trends in Racial/Ethnic Disparity of Health-Related Quality of Life in Older Adults with and without Cancer (1998–2012)

Rincon

Smith

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Non-White cancer survivors often report poorer health compared with Non-Hispanic Whites. Whether those disparities are changing over time is unknown. We examined changes in health-related quality of life (HRQOL) by race/ethnicity from 1998 to 2012 among older adults with and without cancer.Methods: Data from Medicare Advantage beneficiaries were obtained from the linkage between the Medicare Health Outcomes Survey and Surveillance, Epidemiology, and End Results cancer registry data (SEER-MHOS). HRQOL was assessed with the SF-36/ VR-12 Physical and Mental Component Scores (PCS/MCS) and 8 scales (Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Social Functioning, Mental Health, Role-Emotional). Annual average HRQOL scores, adjusting for age at survey, gender, number of comorbidities, education, and SEER registry, were compared over time. Absolute (between-group variance;BGV) and relative (mean log deviation; MLD) indices of disparity were generated using the National Cancer Institute's health disparities calculator (HD Ã Calc). Joinpoint was used to test for significant changes in the slopes of the linear trend lines.Results: Racial/ethnic disparities in MCS increased in absolute and relative terms over time for those with [BGV ¼ 15.8 (95% confidence interval [CI], 10.2-21.6); MLD ¼ 16.2 (95% CI, 10.5-22.1)] and without [BGV ¼ 19.3 (95% CI,); MLD ¼ 19.6 (95% CI, 15.2-24.0)] cancer. PCS disparities over time did not significantly change. Changes in disparities in 5 of 8 HRQOL scales were significant in those with and without cancer.Conclusions: Older adults with cancer show increasing racial/ ethnic disparities in HRQOL, particularly in mental health status.Impact: Future research should evaluate trends in HRQOL and explore factors that contribute to health disparities.

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Section: Discussionmentioning

confidence: 98%

Trends in Racial/Ethnic Disparity of Health-Related Quality of Life in Older Adults with and without Cancer (1998–2012)

Rincon

Smith

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Based on existing evidence, health‐related QoL, including both physical and psychosocial concepts of well‐being, is a subjective sense of health, and correlates with improved survival profiles in patients with lung cancer 23 . Additionally, considering the positive effect of RTCP on QoL in NSCLC patients, we further compared the survival benefit between RTCP and CCP, and found that there was no difference between two interventions.…”

Section: Discussionmentioning

confidence: 99%

Reminiscence therapy‐based care program relieves anxiety, depression, and improves quality of life in post‐operational non‐small cell lung cancer patients

Liu

2021

Clinical Respiratory J

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Objectives The study aimed to explore the effect of reminiscence therapy‐based care program (RTCP) on anxiety, depression, quality of life (QoL), and survival profiles in post‐operational non‐small cell lung cancer (NSCLC) patients. Methods In this randomized, controlled study, a total of 192 newly diagnosed post‐operational NSCLC patients were randomly assigned to control care program (CCP) group (N = 96) or RTCP group (N = 96), and both groups experienced 12‐month intervention and 36‐month follow‐up without intervention. Hospital Anxiety and Depression Scale (HADS) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ‐C30) were evaluated at baseline (M0), month (M)3, M6, and M12. Results Reduced HADS‐anxiety score at M6 and M12, anxiety rate at M12, and anxiety severity at M6 and M12 were observed in RTCP group compared with CCP group. Additionally, HADS‐depression score was decreased at M6 and M12, while both depression rate and severity were of no difference at each time point between two groups. Furthermore, QLQ‐C30 global health status score at M6 and M12, QLQ‐C30 functions score at M12 were increased, while QLQ‐C30 symptoms score was of no difference at each time point in RTCP group compared with CCP group. Regarding survival profiles, Kaplan–Meier curves indicated that disease‐free survival and overall survival were of no difference between two groups, further multivariate Cox’s proportional hazard regression analysis also observed the same trends. Conclusion RTCP effectively relieves anxiety and depression, improves QoL, but did not prolong survival, suggesting its value as a non‐pharmacological approach for post‐operational NSCLC management.

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“…Previous studies with other types of cancer (eg, breast, lung, esophageal, liver) consistently found a correlation between QoL and survival. [6][7][8][9][10][11] Previous studies combined patients with different types of cancer, including a limited number (;6%) of those with pancreatic cancer. 9,10 Most of the data were acquired from randomized trials that included patients who were relatively fit.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Mackay¹,

Latenstein²,

Sprangers

et al. 2020

Journal of the National Comprehensive Cancer Network

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Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015–2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all P<.05) and for patients without resection (ie, overall satisfaction with life, physical and cognitive functioning, QLQ-C30 summary score, fatigue, pain, constipation, diarrhea, and body image; hazard ratios all P<.05). Except for diarrhea, all QoL items accounted for >5% of the additional explained variance and were of added prognostic value. Multivariate analysis using delta QoL revealed that only constipation was of prognostic value for the total cohort, whereas no association with survival was found for subgroups with or without resection. Conclusions: In a multicenter cohort of patients with pancreatic or periampullary carcinoma, QoL scores predicted survival regardless of patient, tumor, and treatment characteristics. QoL scores may thus be used for shared decision-making regarding disease management and treatment choice.

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Investigating the prognostic ability of health-related quality of life on survival: a prospective cohort study of adults with lung cancer

Abstract: This is the first study to compare the prognostic ability of pre-diagnosis, post-diagnosis, and HRQOL changes for OS. The prognostic value of HRQOL at distinct points in the cancer continuum underscores the importance of routine HRQOL monitoring as part of patient-centered cancer care.

Cited by 20 publications

References 19 publications

Trends in Racial/Ethnic Disparity of Health-Related Quality of Life in Older Adults with and without Cancer (1998–2012)

Trends in Racial/Ethnic Disparity of Health-Related Quality of Life in Older Adults with and without Cancer (1998–2012)

Reminiscence therapy‐based care program relieves anxiety, depression, and improves quality of life in post‐operational non‐small cell lung cancer patients

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

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